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    GlossaryGonadotropin-Releasing Hormone Agonists (GnRH analogs)

    medications that initially boost, then suppress, sex hormone production

    Gonadotropin-Releasing Hormone Agonists (GnRH agonists) are medications that mimic the natural hormone GnRH, which regulates the release of other hormones like luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland. Initially, they increase the production of these hormones, but with continuous use, they suppress their release, leading to reduced levels of sex hormones such as testosterone and estrogen. This makes them useful in treating hormone-sensitive conditions like prostate cancer, endometriosis, and certain types of breast cancer.

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      research Management of Transgenderism

      108 citations, February 2013 in “JAMA”
      Transgender treatment includes hormones and surgery, but long-term effects are unknown and counseling is needed.
      Anti-Androgen Treatments for Hirsutism and Acne in Women of Childbearing Age

      research Anti-Androgen Treatments for Hirsutism and Acne in Women of Childbearing Age

      24 citations, January 2010 in “Annales d'endocrinologie”
      For women with moderate to severe unwanted hair growth or acne, birth control pills are the first choice, with other medications like cyproterone, spironolactone, flutamide, or finasteride as alternatives, and permanent hair removal should be done with electrolysis or laser.
      Treatment of Hyperandrogenism in Women

      research Treatment of Hyperandrogenism in Women

      8 citations, January 1996 in “Gynecological Endocrinology”
      Cyproterone acetate is the preferred treatment for women's hyperandrogenism when estrogen/progestogen use is safe.
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