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    GlossaryHypothalamic Amenorrhea

    disruption in brain function stops menstruation due to stress

    Hypothalamic Amenorrhea (HA) is a condition where menstruation stops for several months due to a disruption in the normal functioning of the hypothalamus, a part of the brain that regulates reproductive hormones. This disruption can be caused by factors such as excessive physical stress, significant weight loss, or emotional stress, leading to a decrease in the release of gonadotropin-releasing hormone (GnRH) and subsequently affecting the menstrual cycle.

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      Current Evaluation of Amenorrhea

      research Current Evaluation of Amenorrhea

      30 citations, July 2004 in “Fertility and Sterility”
      Amenorrhea is when a woman doesn't have periods, with primary amenorrhea starting by age 15 or within five years of breast development, and secondary amenorrhea when periods stop for three months. It affects 3-4% of women not pregnant, breastfeeding, or in menopause, mainly due to polycystic ovary syndrome, hypothalamic amenorrhea, hyperprolactinemia, and ovarian failure.
      Current Evaluation of Amenorrhea

      research Current Evaluation of Amenorrhea

      21 citations, September 2004 in “Fertility and Sterility”
      Amenorrhea, or the absence of periods, should be evaluated by age 15 or within five years of early breast development, and is most commonly caused by conditions like polycystic ovary syndrome and hypothalamic amenorrhea.
      Current Evaluation of Amenorrhea

      research Current Evaluation of Amenorrhea

      78 citations, November 2008 in “Fertility and Sterility”
      Amenorrhea is relatively rare and initial testing should check FSH, TSH, and prolactin levels.
      Current Evaluation of Amenorrhea

      research Current Evaluation of Amenorrhea

      38 citations, October 2006 in “Fertility and Sterility”
      The document concludes that identifying the cause of amenorrhea is crucial for proper treatment.

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      community EMA is re-examining Winlevi (clascoterone at lower concentration)

      in Treatment  9 upvotes 1 week ago
      Clascoterone in Winlevi, a topical AR antagonist, is being re-examined due to concerns about HPA axis suppression in adolescents, but it's unlikely to be banned for adult use in androgenetic alopecia (AGA). The European Medicines Agency recommended refusing Winlevi for acne vulgaris, but this may not affect Breezula's approval for AGA.

      community Mechanism of action of alfatradiol (17 alpha estradiol)

      in Research/Science  6 upvotes 1 year ago
      The conversation discusses the mechanism of action of alfatradiol (17 alpha estradiol) in treating hair loss. It explores theories that it either inhibits 5 alpha reductase to prevent T->DHT conversion or aromatizes scalp T into 17-alpha-estradiol to save hair.

      community Injecting estrogen for hairline regrow

      in Chat  266 upvotes 1 month ago
      A user plans to undergo a temporary MtF transformation to regrow hair, using estrogen, RU58841, and Dutasteride, then revert with testosterone. Many users criticize the plan, suggesting alternatives like hair transplants, and emphasize that estrogen is not a reliable solution for hair regrowth.