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GlossaryHypothalamic-Pituitary-Gonadal Axis

regulates reproductive hormones through interactions between brain and gonads

The Hypothalamic-Pituitary-Gonadal (HPG) Axis is a complex set of interactions among the hypothalamus, pituitary gland, and gonads (ovaries in females and testes in males) that regulate reproductive function and hormone production. This system controls the release of hormones like GnRH (gonadotropin-releasing hormone), LH (luteinizing hormone), and FSH (follicle-stimulating hormone), which are crucial for processes such as puberty, menstrual cycles, and sperm production.

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research Sex Differences in the Hypothalamic–Pituitary–Adrenal Axis’ Response to Stress: An Important Role for Gonadal Hormones

197 citations, January 2019 in “Neuropsychopharmacology”

Male and female bodies respond differently to stress, influenced by hormones and development stages, with implications for stress-related diseases.

research Physiology of the Hypothalamic Pituitary Gonadal Axis in the Male

70 citations, March 2016 in “Urologic Clinics of North America”

The document explains how the male reproductive system works, its role in making testosterone, and how conditions like obesity can disrupt it, leading to low testosterone and fertility issues.

research Gonadal Sex Steroids: Production, Action, and Interactions in Mammals

2 citations, November 2012 in “InTech eBooks”

The document concludes that sex hormones are crucial for mammalian reproduction, health, and behavior, and require more research for therapeutic use.

research Testosterone Is a Contraceptive and Should Not Be Used in Men Who Desire Fertility

39 citations, January 2019 in “The World Journal of Men's Health”

Testosterone replacement therapy can prevent men from fathering children and should not be used by those wanting to stay fertile.

research Neuroendocrine Determinants of Polycystic Ovary Syndrome

19 citations, March 2022 in “International Journal of Environmental Research and Public Health”

Certain brain hormones and chemicals are linked to the development of Polycystic Ovary Syndrome.

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community Ru, Stemoxydine or Alfatradiol? What has your experience been with any of these 3?

in Treatment 3 upvotes 1 year ago

The user is seeking advice on which treatment to add to their current regimen for male pattern baldness. They have previously tried Dutasteride, Nizoral, and oral Minoxidil, but experienced continued hair loss. They are specifically asking for experiences with RU58841, Stemoxydine, or Alfatradiol.

community Pyrilutamide: Increased libido. Anyone else experienced something similar with either RU or Pyri?

in Product 18 upvotes 2 years ago

An increase in libido associated with the use of Pyri, and a discussion about how it may be working comparably to other hair loss treatments such as RU58841, Finasteride and Minoxidil.

community My Testosterone is less than 1/3rd In 7 Months since I took Finasteride!

in Finasteride/Dutasteride 113 upvotes 1 year ago

A user experienced a significant drop in testosterone levels after taking finasteride, leading to side effects like low libido and muscle mass loss. Despite its effectiveness for hair, the user decided to stop finasteride due to its impact on hormones, preferring to be bald.

community Mechanism of action of alfatradiol (17 alpha estradiol)

in Research/Science 6 upvotes 5 months ago

The conversation discusses the mechanism of action of alfatradiol (17 alpha estradiol) in treating hair loss. It explores theories that it either inhibits 5 alpha reductase to prevent T->DHT conversion or aromatizes scalp T into 17-alpha-estradiol to save hair.

community Anyone remember Breezula, the promising hairloss drug that was perpetually 3 years away? Well, it's available right now as an acme treatment. Can we just directly apply to the scalp?

in Treatment 41 upvotes 3 years ago

The conversation discusses the availability of Breezula, a drug for hair loss, now being sold as an acne treatment, and whether it can be applied to the scalp. Users express skepticism about new hair loss treatments and suggest waiting for FDA approval.

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