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Glossary Hypothalamic-Pituitary-Gonadal Axis

regulates reproductive hormones through interactions between brain and gonads

The Hypothalamic-Pituitary-Gonadal (HPG) Axis is a complex set of interactions among the hypothalamus, pituitary gland, and gonads (ovaries in females and testes in males) that regulate reproductive function and hormone production. This system controls the release of hormones like GnRH (gonadotropin-releasing hormone), LH (luteinizing hormone), and FSH (follicle-stimulating hormone), which are crucial for processes such as puberty, menstrual cycles, and sperm production.

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research Sex differences in the hypothalamic–pituitary–adrenal axis’ response to stress: an important role for gonadal hormones

197 citations , January 2019 in “Neuropsychopharmacology”

This review discusses sex differences in the neuroendocrine response to stress, focusing primarily on rodent studies, and highlights open questions about the roles of gonadal hormones and sex chromosomes.

research Physiology of the Hypothalamic Pituitary Gonadal Axis in the Male

70 citations , March 2016 in “Urologic Clinics of North America”

This article reviews the coordination of the hypothalamic-pituitary-gonadal axis, male fertility, and therapies for hypogonadism, but reports no new clinical findings.

research Age-related changes in endogenous glucocorticoids, gonadal steroids, endocannabinoids and their ratios in plasma and hair from the male C57BL/6 mice

11 citations , October 2020 in “General and comparative endocrinology”

This study found that age-related fluctuations in hormones and endocannabinoids in male C57BL/6 mice showed specific patterns, with peak values observed around 2.7 to 3.4 months, with these patterns seen in both plasma and hair but with different magnitudes.

research Gonadal Sex Steroids: Production, Action and Interactions in Mammals

2 citations , November 2012 in “InTech eBooks”

The document concludes that sex hormones are crucial for mammalian reproduction, health, and behavior, and require more research for therapeutic use.

research Gonadal Function in Men with Cushing Syndrome

1 citations , November 2013

This study identified hypogonadism in 65% of men with Cushing syndrome, suggesting glucocorticoid excess may affect the hypothalamic-pituitary level or testosterone metabolism.

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community Methods Of Staying Safe On Ru58841 - My 2 Cents

in Research/Science 21 upvotes 1 year ago

RU58841 is used topically to prevent hair loss by blocking DHT, with suggestions to drink grapefruit juice, take breaks, avoid microneedling, and use lower concentrations to reduce side effects. Users discuss applying it at night to minimize systemic absorption.

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in Finasteride/Dutasteride 100 upvotes 7 months ago

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340 upvotes 9 months ago

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community How I recovered from 4+ years of severe balding ages 20-24 by dieting, lifestyle changes and ONLY using topical minoxidil

in Progress Pictures 473 upvotes 1 year ago

A user reversed severe hair loss with dieting, lifestyle changes, and topical minoxidil, highlighting reduced inflammation and body fat. The conversation debates finasteride's effectiveness and the impact of diet and lifestyle on hair health.

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