Neuroendocrine Determinants of Polycystic Ovary Syndrome

The document discusses the role of neuroendocrine determinants in Polycystic Ovary Syndrome (PCOS), a common endocrine disorder in women. It highlights the role of neurohormones such as Gonadotropin-releasing hormone (GnRH), kisspeptin, and Neurokinin B (NKB), and neurotransmitters in the development of PCOS. The document reveals that women with PCOS have a persistent rapid GnRH pulse frequency and higher serum kisspeptin levels, suggesting overactivity in the kisspeptin system. This overactivity leads to hypothalamic-pituitary-gonadal axis overactivity, menstrual disorders, hyperandrogenemia, and hyperandrogenism. Abnormal regulation of NKB is also suspected to contribute to PCOS development. The document concludes that further studies are needed to fully understand the neuroendocrine mechanisms behind PCOS.