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GlossaryGonadotropin-releasing hormone (GnRH)

regulates release of reproductive hormones from the pituitary gland

Gonadotropin-releasing hormone (GnRH) is a key hormone produced in the hypothalamus of the brain. It regulates the release of two other important hormones from the pituitary gland: luteinizing hormone (LH) and follicle-stimulating hormone (FSH). These hormones are crucial for reproductive function, including the development of eggs in ovaries and sperm in testes.

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research An Open Randomized Comparative Study of an Oral Contraceptive Containing Ethinyl Estradiol and Cyproterone Acetate with and without the GnRH Analogue Goserelin in the Long-Term Treatment of Hirsutism

18 citations, January 1996 in “Gynecologic and obstetric investigation”

The oral contraceptive alone is the preferred treatment for hirsutism, as adding the GnRH analog showed no significant benefit.

research Sertoli-Leydig Cell Tumors: Hormonal Profile After Dynamic Test with GnRH Analogue Triptorelin Represents a Useful Tool to Evaluate Tumoral Hyperandrogenism

5 citations, October 2014 in “Gynecological Endocrinology”

Triptorelin helps evaluate hormone production in Sertoli-Leydig cell tumors.

Utilization of Gonadotrophin-Releasing Hormone Analogue to Differentiate Ovarian from Adrenal Hyperandrogenism in Postmenopausal Women

research Utilization of Gonadotrophin-Releasing Hormone Analogue to Differentiate Ovarian from Adrenal Hyperandrogenism in Postmenopausal Women

4 citations, November 2018 in “Endocrinology, Diabetes & Metabolism Case Reports”

GnRH analogue can help diagnose ovarian causes of high testosterone in postmenopausal women when scans don't show the cause.

research Clinical Utility of GnRH Analogues in Female Androgen Excess: Highlighting Diagnostic and Therapeutic Applications

1 citations, September 2023 in “JCEM case reports”

GnRH analogues are effective for diagnosing and treating female androgen excess, offering a non-surgical option.

research Effect of a Six-Month Treatment Regimen of Metformin on 17-Hydroxyprogesterone Responses to GnRH Agonist in Polycystic Ovary Syndrome

September 2002 in “Fertility and sterility”

Metformin can start ovulation and may lower 17P response in PCOS, but six months is too short to improve hair growth or change body fat distribution.

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community 35 MtF | 16 Months | Minoxidil + Dutasteride + Microneedling + Exosomes. Note that since I'm early in my transition (and I was coming from a bald state), I still have short hair. Very few MtF progress pictures here, I figure this might help some of you.

in Transgender 125 upvotes 11 months ago

A 35-year-old transitioning female (MtF) shared her hair regrowth journey using Minoxidil, Dutasteride, Microneedling, and Exosomes, starting from a bald state. Commenters discussed the impressive results, skin care routine, and the effects of estrogen on hair and skin.

community Insane MTF recovery 18 months blocking androgens

in Progress Pictures 145 upvotes 1 year ago

Hair loss recovery using estrogen and anti-androgen treatment for 18 months showed significant improvement. However, results vary and alternative treatments like RU58841 and Dutasteride may work without systemic feminization.

community My Testosterone is less than 1/3rd In 7 Months since I took Finasteride!

in Finasteride/Dutasteride 113 upvotes 1 year ago

A user experienced a significant drop in testosterone levels after taking finasteride, leading to side effects like low libido and muscle mass loss. Despite its effectiveness for hair, the user decided to stop finasteride due to its impact on hormones, preferring to be bald.

community Physician here AMA – 30M oral Fin 1-1.25 mg daily

in Update 47 upvotes 2 years ago

Hair loss treatments, specifically the use of finasteride, microneedling and potentially oral minoxidil. People discussed their experiences with finasteride, its effects on sexual behaviors, as well as potential solutions such as tadalafil or using other growth factor signal peptides for hope in curing male pattern baldness.

community Two Great Articles on NCBI That Summarize What We Actually Know About Finasteride Side Effects

in Finasteride 80 upvotes 5 years ago

The side effects of taking finasteride as a treatment for hair loss, with particular focus on its sexual and psychiatric side effects; research has indicated that there are high and low outliers in terms of prevalence of sexual side effects, but it is usually between 3-5%, while evidence of lasting sexual side effects comes from lower quality sources.