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GlossaryKisspeptin

protein that triggers hormone release for puberty and fertility

Kisspeptin is a protein that plays a crucial role in the regulation of the reproductive system by triggering the release of hormones necessary for puberty and fertility. It acts on the hypothalamus in the brain to stimulate the secretion of gonadotropin-releasing hormone (GnRH), which in turn influences the production of sex hormones like estrogen and testosterone.

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research Kisspeptin and LH Pulsatile Temporal Coupling in PCOS Patients

49 citations, May 2018 in “Endocrine”

Women with regular menstrual cycles and PCOS have linked kisspeptin and LH hormone patterns, unlike those with irregular cycles.

research Microglia: Sculptors of the Polycystic Ovary Syndrome-Like Brain?

1 citations, June 2023 in “Reproduction”

Microglia, the brain's immune cells, may contribute to Polycystic Ovary Syndrome (PCOS) by altering the female brain's structure and function, with kisspeptin neurons and GABA neurotransmitters also playing a role.

research An Integrative View of Mammalian Seasonal Neuroendocrinology

85 citations, May 2019 in “Journal of neuroendocrinology”

The article concludes that better understanding gene regulation related to seasonal changes can offer insights into the mechanisms of seasonal timing in mammals.

research In Search of New Therapeutics: Molecular Aspects of the PCOS Pathophysiology - Genetics, Hormones, Metabolism and Beyond

44 citations, September 2020 in “International Journal of Molecular Sciences”

New treatments are needed for PCOS that target its genetic, hormonal, and metabolic causes.

research Neuroendocrine Determinants of Polycystic Ovary Syndrome

19 citations, March 2022 in “International Journal of Environmental Research and Public Health”

Certain brain hormones and chemicals are linked to the development of Polycystic Ovary Syndrome.

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