In Search of New Therapeutics: Molecular Aspects of the PCOS Pathophysiology - Genetics, Hormones, Metabolism and Beyond

September 2020 in “ International Journal of Molecular Sciences ”

Agata Wawrzkiewicz-Jałowiecka, Karolina Kowalczyk, Paulina Trybek, Tomasz Jarosz, Patrycja Radosz, Marcin Setlak, Paweł Madej

PCOS Polycystic Ovary Syndrome CYP11a CYP17 anti-Müllerian hormone AMH insulin resistance inositols GABA gamma-aminobutyric acid kisspeptin berberine naringenin androgenic symptoms

Studysummary This review discusses the disruption of hormonal and metabolic rhythms in polycystic ovary syndrome and explores potential drug targets to address its molecular causes, without providing new clinical results.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The document reviewed the molecular aspects of Polycystic Ovary Syndrome (PCOS) pathophysiology, focusing on genetics, hormones, and metabolism. It highlighted the complex interplay of genetic predispositions, hormonal imbalances, and metabolic dysfunctions contributing to PCOS. Key findings included the role of genes like CYP11a and CYP17, the impact of elevated anti-Müllerian hormone (AMH) levels, and the association of insulin resistance with PCOS. The review emphasized the need for novel therapies targeting the molecular causes of PCOS, as current treatments often failed to address issues like ovulation induction, insulin resistance, and androgenic symptoms. Promising substances for future treatments included inositols, GABA, kisspeptin, berberine, and naringenin. The document underscored the need for further research to optimize PCOS treatments.

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