Anti-Müllerian Hormone Gene Polymorphism Is Associated With Androgen Levels in Chinese Polycystic Ovary Syndrome Patients With Insulin Resistance

    January 2016 in “ Journal of Assisted Reproduction and Genetics ”
    Mengxue Zheng, Yan Li, Rong Hu, Fei-Miao Wang, Xiaomei Zhang, Bing Guan
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    Studysummary This study suggests that genetic variations in the AMH signal pathway may be linked to susceptibility and phenotype variations in PCOS among women with insulin resistance.
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    The study, conducted on 141 polycystic ovary syndrome (PCOS) patients and 123 normal women, explored the relationship between anti-Müllerian hormone (AMH) gene polymorphisms and PCOS in Chinese women with insulin resistance (IR). The findings indicated that AMH gene polymorphisms were significantly different in IR-PCOS women compared to controls and were associated with higher serum levels of luteinizing hormone (LH), testosterone, and HOMA-IR (a measure of insulin resistance). No significant differences were found in non-IR-PCOS and normal groups, nor were there any impacts from AMH and AMHRII gene-gene interactions. The study suggests that AMH gene polymorphisms may influence the susceptibility and phenotype of PCOS in the presence of insulin resistance.
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