Anti-Müllerian Hormone Gene Polymorphism Is Associated With Androgen Levels in Chinese Polycystic Ovary Syndrome Patients With Insulin Resistance

The study, conducted on 141 polycystic ovary syndrome (PCOS) patients and 123 normal women, explored the relationship between anti-Müllerian hormone (AMH) gene polymorphisms and PCOS in Chinese women with insulin resistance (IR). The findings indicated that AMH gene polymorphisms were significantly different in IR-PCOS women compared to controls and were associated with higher serum levels of luteinizing hormone (LH), testosterone, and HOMA-IR (a measure of insulin resistance). No significant differences were found in non-IR-PCOS and normal groups, nor were there any impacts from AMH and AMHRII gene-gene interactions. The study suggests that AMH gene polymorphisms may influence the susceptibility and phenotype of PCOS in the presence of insulin resistance.