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    Community 5

    1. After praising finasteride on this sub for a while I realised it gave me Brain Fog. I think its related to inhibiting GABA and interferring with mirtazapine (an antidepressant). Reddit · 1 Jan 2020
    2. 5 alpha reductase type 1 is in brain tissue producing the main endogenous gabaergic allopregnanolone, not 2. How can finasteride as a 5ar2 lower that? Reddit · 3 Oct 2024
    3. DHT and 5AR respect post, it's importance within the brain Reddit · 3 Mar 2024
    4. Progressive insomnia (treatment-resistant) due to Finasteride Reddit · 1 Jun 2022
    5. What is the real impact of dutasteride on neurosteroids? A little review of 2 scientific datas Reddit · 25 Jun 2024

    Research 10 of 1000+

    1. Stress-Induced Deoxycorticosterone-Derived Neurosteroids Modulate GABA<sub>A</sub>Receptor Function and Seizure Susceptibility Journal of Neuroscience · 2002 · 269 citations
    2. Neurosteroidogenesis Is Required for the Physiological Response to Stress: Role of Neurosteroid-Sensitive GABA<sub>A</sub>Receptors Journal of Neuroscience · 2011 · 248 citations
    3. Neurosteroid Synthesis-Mediated Regulation of GABA<sub>A</sub>Receptors: Relevance to the Ovarian Cycle and Stress Journal of Neuroscience · 2007 · 238 citations
    4. Production of 5α-Reduced Neurosteroids Is Developmentally Regulated and Shapes GABA<sub>A</sub>Miniature IPSCs in Lamina II of the Spinal Cord Journal of Neuroscience · 2004 · 88 citations
    5. Changes in Expression and Function of Extrasynaptic GABA<sub>A</sub>Receptors in the Rat Hippocampus during Pregnancy and after Delivery Journal of Neuroscience · 2009 · 86 citations
    6. Epoxy Fatty Acids and Inhibition of the Soluble Epoxide Hydrolase Selectively Modulate GABA Mediated Neurotransmission to Delay Onset of Seizures PLoS ONE · 2013 · 60 citations
    7. Social isolation‐induced increase in α<sub>4</sub>and δ subunit gene expression is associated with a greater efficacy of ethanol on steroidogenesis and GABA<sub>A</sub>receptor function Journal of Neurochemistry · 2006 · 60 citations
    8. FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation Autophagy · 2014 · 60 citations
    9. GABAergic neurosteroids mediate the effects of ethanol on long‐term potentiation in rat hippocampal slices European Journal of Neuroscience · 2007 · 48 citations
    10. Neuroactive steroids inhibit spinal reflex potentiation by selectively enhancing specific spinal GABAA receptor subtypes Pain · 2009 · 44 citations
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