Enhanced Remyelination During Late Pregnancy: Involvement of the GABAergic System

The study found that late pregnancy enhanced remyelination in rats with demyelination in the corpus callosum compared to virgin and postpartum rats. This promyelinating effect was linked to the GABAergic system, as blocking the GABA A receptor or inhibiting 5α-reductase, which is crucial for producing the GABA A receptor activator allopregnanolone, negated the effect. This suggested that the protective effect of late pregnancy on remyelination involved the GABAergic system.