14 citations
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March 2017 in “Brain research” This study suggests that ovarian cycle-related progesterone and neurosteroids regulate α2-subunit expression of GABA-A receptors in the hippocampus through a pathway independent of progesterone receptors, potentially affecting brain conditions linked to the menstrual cycle.
1 citations
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April 2011 in “The FASEB Journal” This study suggests that the regulation of GABA‐A δ subunit expression by ovarian progesterone-derived neurosteroids may influence seizure susceptibility in catamenial epilepsy.
March 2008 in “The FASEB Journal” This study found that neurosteroid withdrawal significantly increased hippocampal GABA-A receptor α4 subunit expression in female mice, confirming an association between neurosteroid withdrawal and altered receptor expression.
12 citations
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February 2017 in “Journal of neuroscience research” This study suggests that extrasynaptic δGABA-A receptors may have a protective role in modulating the severity of catamenial-like seizures by influencing neurosteroid and benzodiazepine responses in mice.
40 citations
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December 2019 in “Neurobiology of Stress” This review focuses on neuroactive steroids' influence on GABA-ergic signaling and discusses challenges in developing them for various therapeutic uses, citing recent excitement from FDA approval of allopregnanolone for postpartum depression but reporting no new results.