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5 / 5 resultslearn Valproic acid
 an anticonvulsant repurposed for hair loss via histone inhibition  
 learn Gamma linolenic acid
learn Osteopontin
 signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss  
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Research
5 / 1000+ resultsresearch Sodium Valproate Improves Skin Flap Survival via Gamma-Aminobutyric Acid and Histone Deacetylase Inhibitory System
 Sodium valproate helps skin healing by affecting GABA and histone deacetylase.  
 research Alleviation of Mechanical Allodynia by 14,15-Epoxyeicosatrienoic Acid in a Central Poststroke Pain Model: Possible Role of Allopregnanolone and Delta-Subunit-Containing Gamma-Aminobutyric Acid A Receptors
 14,15-EET may help reduce poststroke pain by affecting certain brain proteins.  
 
  research Synthesis and Actions of 5α-Reduced Metabolites of Testosterone in the Nervous System
 Testosterone and its metabolites affect brain functions and could help treat neurological disorders.  
 research In Search of New Therapeutics: Molecular Aspects of the PCOS Pathophysiology - Genetics, Hormones, Metabolism and Beyond
 New treatments are needed for PCOS that target its genetic, hormonal, and metabolic causes.  
 
  research Microglia: Sculptors of the Polycystic Ovary Syndrome-Like Brain?
 Microglia, the brain's immune cells, may contribute to Polycystic Ovary Syndrome (PCOS) by altering the female brain's structure and function, with kisspeptin neurons and GABA neurotransmitters also playing a role.  
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5 / 26 resultscommunity Finasteride does deplete important nuero-active steroids
 Finasteride can reduce neuroactive steroids, causing side effects like depression, anxiety, and sexual dysfunction. Some users experience persistent symptoms after stopping finasteride, while others use alternative treatments like topical solutions.  
 community DHT Oily Scalp Dangers: Theory of an Oily Scalp and PPAR-GAMMA Dysregulation
 Excessive scalp sebum, worsened by DHT, can lead to inflammation and hair loss, with clascoterone mentioned as a treatment. Diet changes seem ineffective for scalp sebum, and treatments like minoxidil and finasteride are suggested.  
 community Is tazarotene potentially better than tretinoin in combination with topical minoxidil?
 Tazarotene may be more effective than tretinoin when combined with topical minoxidil for hair loss due to its selective binding to RAR-beta and gamma, though it can cause irritation. Tazarotene's potency can lead to indirect inflammatory reactions despite potentially causing less irritation than tretinoin.  
 
  community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied
 Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.  
 community Has anyone here tried taking GLA supplements?
 GLA may help with hair loss due to its anti-inflammatory properties and 5ar enzyme inhibition. It's considered potentially more important than biotin, especially for those already using finasteride and dutasteride.