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    Glossary Gamma Delta T Cells

    unique immune cells with distinct receptors for rapid pathogen response

    Gamma Delta T Cells (γδ T cells) are a unique subset of T lymphocytes that play a crucial role in the immune system. Unlike the more common alpha-beta T cells, γδ T cells have a distinct T-cell receptor (TCR) composed of one gamma chain and one delta chain. They are involved in both innate and adaptive immunity, providing rapid responses to a wide range of pathogens and participating in tissue repair and homeostasis.

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    1. Perforins Expression by Cutaneous Gamma Delta T Cells Frontiers in Immunology · 2020 · 13 citations
    2. Gamma/delta T cells and human skin reactivity to heavy metals Archives of Dermatological Research · 1995 · 13 citations
    3. Increased proliferation of epidermal gamma delta T cells and expression of the transmembrane protein, BST2, in Alopecia areata 2022 · 2 citations
    4. TLR9 activation in large wound induces tissue repair and hair follicle regeneration via gamma delta T cells bioRxiv (Cold Spring Harbor Laboratory) · 2024
    5. Skin Gamma Delta T Cell Gene Expression Highlights Stress Response in Alopecia Areata 2258104 The Journal of Immunology · 2026
    6. Butyrophilin-like 2 (BTNL2) to the Rescue: controlling autoaggressive dermal gamma delta (GD) T lymphocytes in human hair follicles (HFs) 3747 The Journal of Immunology · 2025
    7. γδ T cells mediate a requisite portion of a wound healing response triggered by cutaneous poxvirus infection bioRxiv (Cold Spring Harbor Laboratory) · 2020 · 1 citations
    8. Human regulatory γδT lymphocytes as novel autoimmunity-protective cells: Lessons from alopecia areata 2024
    9. Decision letter: Stimulation of hair follicle stem cell proliferation through an IL-1 dependent activation of γδT-cells 2017
    10. Effects of Imiquimod on Hair Follicle Stem Cells and Hair Cycle Progression 2016 · 25 citations
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