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    Glossary Gamma Delta T Cells

    unique immune cells with distinct receptors for rapid pathogen response

    Gamma Delta T Cells (γδ T cells) are a unique subset of T lymphocytes that play a crucial role in the immune system. Unlike the more common alpha-beta T cells, γδ T cells have a distinct T-cell receptor (TCR) composed of one gamma chain and one delta chain. They are involved in both innate and adaptive immunity, providing rapid responses to a wide range of pathogens and participating in tissue repair and homeostasis.

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    1. Perforins Expression by Cutaneous Gamma Delta T Cells Frontiers in Immunology · 2020 · 13 citations
    2. Gamma/delta T cells and human skin reactivity to heavy metals Archives of Dermatological Research · 1995 · 13 citations
    3. Increased proliferation of epidermal gamma delta T cells and expression of the transmembrane protein, BST2, in Alopecia areata 2022 · 2 citations
    4. TLR9 activation in large wound induces tissue repair and hair follicle regeneration via gamma delta T cells bioRxiv (Cold Spring Harbor Laboratory) · 2024
    5. Skin Gamma Delta T Cell Gene Expression Highlights Stress Response in Alopecia Areata 2258104 The Journal of Immunology · 2026
    6. Butyrophilin-like 2 (BTNL2) to the Rescue: controlling autoaggressive dermal gamma delta (GD) T lymphocytes in human hair follicles (HFs) 3747 The Journal of Immunology · 2025
    7. γδ T cells mediate a requisite portion of a wound healing response triggered by cutaneous poxvirus infection bioRxiv (Cold Spring Harbor Laboratory) · 2020 · 1 citations
    8. Human regulatory γδT lymphocytes as novel autoimmunity-protective cells: Lessons from alopecia areata 2024
    9. Decision letter: Stimulation of hair follicle stem cell proliferation through an IL-1 dependent activation of γδT-cells 2017
    10. Effects of Imiquimod on Hair Follicle Stem Cells and Hair Cycle Progression 2016 · 25 citations
    11. 315 Butyrophilin-like 2 (BTNL2) controls auto-aggressive dermal γδT lymphocytes that attack human hair follicles. Journal of Investigative Dermatology · 2025
    12. Cell Population Dynamics in Wound-Induced Hair Follicle Neogenesis Model Life · 2022
    13. Local IL-17 orchestrates skin aging bioRxiv (Cold Spring Harbor Laboratory) · 2022 · 1 citations
    14. Identification of Immune Microenvironment Changes, Immune-Related Pathways and Genes in Male Androgenetic Alopecia Research Square (Research Square) · 2023
    15. Fibroblast growth factors: key players in regeneration and tissue repair Development · 2017 · 154 citations
    16. Impaired Notch‐MKP‐1 signalling in hidradenitis suppurativa: an approach to pathogenesis by evidence from translational biology Experimental dermatology · 2013 · 112 citations
    17. Hair follicle immune privilege and its collapse in alopecia areata Experimental dermatology · 2020 · 134 citations
    18. Expression of Peroxisome Proliferator Activated Receptors (PPARs) in Human Hair Follicles and PPARα Involvement in Hair Growth Acta dermato-venereologica · 2000 · 51 citations
    19. Recent Advances in the Pathogenesis of Autoimmune Hair Loss Disease Alopecia Areata Clinical and Developmental Immunology · 2013 · 106 citations
    20. Regulatory T cells in skin Immunology · 2017 · 110 citations
    21. γδ17 T cell-stromal networks modulate matrix composition and vascularity in foreign body response 2026 · 1 citations
    22. Adult epidermal Notch activity induces dermal accumulation of T cells and neural crest derivatives through upregulation of jagged 1 Development · 2010 · 34 citations
    23. Regulatory T cells are required for normal and activin‐promoted wound repair in mice European Journal of Immunology · 2018 · 29 citations
    24. Exploring the Drug Repurposing Versatility of Valproic Acid as a Multifunctional Regulator of Innate and Adaptive Immune Cells Journal of immunology research · 2019 · 47 citations
    25. Integrated single-cell chromatin and transcriptomic analyses of peripheral immune cells in patients with alopecia areata Frontiers in Immunology · 2025 · 4 citations
    26. Immune cell regulation of the hair cycle Experimental Dermatology · 2020 · 27 citations
    27. Humanized CXCL12 antibody delays onset and modulates immune response in alopecia areata mice: insights from single-cell RNA sequencing Frontiers in Immunology · 2024 · 7 citations
    28. Pro-inflammatory Vδ1+T-cells infiltrates are present in and around the hair bulbs of non-lesional and lesional alopecia areata hair follicles Journal of Dermatological Science · 2020 · 23 citations
    29. Conserved γδ T cell selection by BTNL proteins limits progression of human inflammatory bowel disease Science · 2023 · 60 citations
    30. Dendritic epidermal T cells secreting exosomes promote the proliferation of epidermal stem cells to enhance wound re-epithelialization Stem Cell Research & Therapy · 2022 · 24 citations