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GlossaryPeroxisome Proliferator-Activated Receptor Gamma

nuclear receptor protein regulating genes for fat storage and glucose metabolism

Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) is a type of nuclear receptor protein that regulates the expression of specific genes involved in fat storage, glucose metabolism, and inflammation. It plays a crucial role in the development of adipose tissue and is a target for drugs used to treat conditions like type 2 diabetes and metabolic syndrome.

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Preservation of Sebaceous Glands and Peroxisome Proliferator-Activated Receptor Gamma Expression in Central Centrifugal Cicatricial Alopecia

research Preservation of Sebaceous Glands and Peroxisome Proliferator-Activated Receptor Gamma Expression in Central Centrifugal Cicatricial Alopecia

1 citations, July 2018 in “Journal of The American Academy of Dermatology”

Sebaceous glands are often preserved and PPARy expression is constant in some cases of Central Centrifugal Cicatricial Alopecia.

Peroxisome Proliferator Activated Receptor-Gamma Tissue Expression and Gene Polymorphism in Alopecia Areata in an Egyptian Sample

research Peroxisome Proliferator Activated Receptor-Gamma Tissue Expression and Gene Polymorphism in Alopecia Areata in an Egyptian Sample

October 2023 in “Benha Journal of Applied Sciences”

PPAR-γ may be a key target for treating alopecia areata and other skin conditions.

Canonical and Dominant Negative Peroxisome Proliferator-Activated Receptor Gamma Isoforms Are Differentially Expressed in Human Skin and Skin Appendages

research Canonical and Dominant Negative Peroxisome Proliferator-Activated Receptor Gamma Isoforms Are Differentially Expressed in Human Skin and Skin Appendages

November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

Different types of PPARγ are found in varying amounts in human skin and its parts, which could affect how skin treatments work.

research Expression of Steroidogenic Enzymes in Human Sebaceous Glands

25 citations, June 2014 in “Journal of Endocrinology/Journal of endocrinology”

Human sebaceous glands contain enzymes that affect androgen production and may influence sebum production and acne.

research Sebaceous Immunobiology: Skin Homeostasis, Innate Immunity Coordination, Inflammatory Response, and Disease Associations

21 citations, November 2022 in “Frontiers in immunology”

Sebaceous glands play a key role in skin health, immunity, and various skin diseases.

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community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 4 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.