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    Glossary Peroxisome Proliferator-Activated Receptor Gamma

    nuclear receptor protein regulating genes for fat storage and glucose metabolism

    Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) is a type of nuclear receptor protein that regulates the expression of specific genes involved in fat storage, glucose metabolism, and inflammation. It plays a crucial role in the development of adipose tissue and is a target for drugs used to treat conditions like type 2 diabetes and metabolic syndrome.

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    Research 30 of 847

    1. Preservation of sebaceous glands and peroxisome proliferator-activated receptor gamma expression in central centrifugal cicatricial alopecia Journal of The American Academy of Dermatology · 2018 · 1 citations
    2. Peroxisome Proliferator Activated Receptor-Gamma Tissue Expression and Gene Polymorphism in Alopecia Areata in an Egyptian Sample Benha Journal of Applied Sciences · 2023
    3. Peroxisome Proliferator Activated Receptors Gamma Serum levels and Gene Polymorphism in Frontal Fibrosing Alopecia: A Case Control Study Research Square (Research Square) · 2022
    4. Peroxisome Proliferator–Activated Receptor-γ−Mediated Signaling Regulates Mitochondrial Energy Metabolism in Human Hair Follicle Epithelium Journal of Investigative Dermatology · 2018 · 17 citations
    5. 223 Canonical and Dominant Negative Peroxisome Proliferator-Activated Receptor γ Isoforms are Differentially Expressed in Human Skin and Skin Appendages 2022
    6. Expression of Peroxisome Proliferator Activated Receptors (PPARs) in Human Hair Follicles and PPARα Involvement in Hair Growth Acta dermato-venereologica · 2000 · 51 citations
    7. Inhibition of Cholesterol Biosynthesis Modulates Epithelial-Mesenchymal Transition in Primary Cicatricial Alopecia Through TGFβ and Angiotensin Receptors Journal of Endocrinology and Reproduction · 2023
    8. TGFβ signaling regulates lipogenesis in human sebaceous glands cells BMC Dermatology · 2013 · 44 citations
    9. Expression of steroidogenic enzymes in human sebaceous glands 2014 · 25 citations
    10. Sebaceous immunobiology - skin homeostasis, pathophysiology, coordination of innate immunity and inflammatory response and disease associations Frontiers in immunology · 2022 · 21 citations
    11. Adipose and Hair Function: An aPPARent Connection Journal of Investigative Dermatology · 2018 · 7 citations
    12. A new target for squamous cell skin cancer? Experimental Dermatology · 2014 · 6 citations
    13. Hot Stuff: Thermal Imaging Aids in Cellulitis Diagnosis Journal of Investigative Dermatology · 2018 · 4 citations
    14. Treatment of Cultured Sebocytes with an EGFR Inhibitor Does Not Lead to Significant Upregulation of Inflammatory Biomarkers Annals of Dermatology · 2011 · 3 citations
    15. Deciphering the Skin Anti-Aging and Hair Growth Promoting Mechanisms of Opophytum forskahlii Seed Oil via Network Pharmacology International Journal of Molecular Sciences · 2025
    16. Early skin seeding regulatory T cells modulate PPARγ-dependent skin pigmentation bioRxiv (Cold Spring Harbor Laboratory) · 2023
    17. 1405 Cellular and molecular characterization of sebaceous gland self-renewal and regeneration following complete genetic ablation Journal of Investigative Dermatology · 2023
    18. SnapshotDx Quiz: December 2018 Journal of Investigative Dermatology · 2018
    19. Faculty Opinions recommendation of Hair follicle stem cell-specific PPARgamma deletion causes scarring alopecia. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2009
    20. 686 Topical melatonin unfolds differential anti-aging effects in human skin by inhibiting mTORC1 activity via TSC2 stimulation Journal of Investigative Dermatology · 2024
    21. PPAR-<i>γ</i> Agonists and Their Role in Primary Cicatricial Alopecia PPAR Research · 2017 · 38 citations
    22. Adipose transcriptome in the scalp of androgenetic alopecia Frontiers in Medicine · 2023
    23. Cicatricial alopecia: What’s new in etiology? European Journal of Inflammation · 2015
    24. The role of PPAR<i>γ</i>-mediated signalling in skin biology and pathology: new targets and opportunities for clinical dermatology Experimental Dermatology · 2015 · 84 citations
    25. Peroxisome proliferator-activated receptors (PPARs) and PPAR agonists: the ‘future’ in dermatology therapeutics? Archives of dermatological research · 2015 · 60 citations
    26. Lichen Planopilaris Treated With a Peroxisome Proliferator–Activated Receptor γ Agonist Archives of dermatology · 2009 · 105 citations
    27. Peroxisome proliferator-activated receptors-mediated diabetic wound healing regulates endothelial cells’ mitochondrial function via sonic hedgehog signaling Burns & Trauma · 2025 · 5 citations
    28. Contributions of peroxisome proliferator-activated receptor β/δ to skin health and disease BioMolecular Concepts · 2012 · 12 citations
    29. The role of nuclear hormone receptors in cutaneous wound repair Cell Biochemistry and Function · 2014 · 68 citations
    30. Mechanisms of Puerariae Lobatae Radix in regulating sebaceous gland secretion: insights from network pharmacology and experimental validation Frontiers in Pharmacology · 2024 · 3 citations