Cicatricial Alopecia Symposium 2011: Lipids, Inflammation, and Stem Cells

    May 2012 in “ Journal of Investigative Dermatology ”
    Pratima Karnik, Kurt S. Stenn
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    TLDR The symposium concluded that a specific lipid might cause hair loss, inflammation is a key factor, and stem cells in bald scalps aren't working right, suggesting new treatment targets.
    The Cicatricial Alopecia Symposium in 2011, attended by approximately 90 scientists, focused on the roles of lipids, inflammation, and stem cells in hair loss. The symposium found that prostaglandin D2, a lipid, was present in higher levels in bald scalps, suggesting its role in hair loss. Inflammation was identified as a key factor in cicatricial alopecia, and anti-inflammatory treatments were suggested as potential management strategies. The symposium also found that while stem cells were present in bald scalps, they were not functioning properly, possibly due to inflammation or lipid changes. The potential of PPARγ and AhR as therapeutic targets was discussed, with 50% of lichen planopilaris patients responding to treatment with Pioglitazone, a PPARγ agonist. The symposium concluded with the need for better understanding of the role of lipids in hair loss and the role of the sebaceous gland in hair biology.
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      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 7 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community You will lose hair if your prostaglandins aren't in balance

      in Research/Science  53 upvotes 1 week ago
      Prostaglandin balance affects hair loss, particularly in conditions like Lichen Planopilaris, where an imbalance can lead to hair follicle damage. Treatments mentioned include prostaglandin analogs and Pioglitazone HCL, with a focus on maintaining prostaglandin equilibrium for potential hair regrowth.

      community I am a dermatologist with a clinical interest in alopecia. AMA

      in Will treatment work for me? 2 years ago
      In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

      community Losing Hair on Dutasteride? You might have LPP

      in Research/Science  94 upvotes 3 weeks ago
      Men with hair loss might have lichen planopilaris (LPP), which can mimic androgenetic alopecia, leading to misdiagnosis and ineffective treatment with finasteride or dutasteride. Proper diagnosis, including biopsies, is crucial to distinguish between androgenetic alopecia and conditions like LPP.

      community Totally confused by doctors opinions, would appreciate some clarity

      in Treatment  1 upvotes 3 months ago
      The user is experiencing hair loss and confusion over conflicting medical advice, with treatments including minoxidil, finasteride, and topical corticosteroids. They are unsure about the necessity of a biopsy and the timing of using minoxidil, while also considering the impact of potential androgenetic alopecia and telogen effluvium.

      community Finasteride not working isnt it MPB?

      in Finasteride/Dutasteride  5 upvotes 11 months ago
      A user is concerned that finasteride isn't working for their hair loss, questioning if it's due to male pattern baldness or low iron levels. They are advised to take finasteride daily and get blood work done.

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