Through the Lens of Hair Follicle Neogenesis: A New Focus on Mechanisms of Skin Regeneration After Wounding

    October 2019 in “ Seminars in Cell & Developmental Biology ”
    Eric M. Wier, Luis A. Garza
    Studysummary This article discusses the advances in understanding wound-induced hair follicle neogenesis (WIHN) and highlights the roles of specific signaling pathways and cellular plasticity, noting no clinical results but suggesting potential areas for further research.
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    Research cited in this study 38

    1. Noncoding dsRNA Induces Retinoic Acid Synthesis to Stimulate Hair Follicle Regeneration via TLR3 Nature Communications · 2019
    2. Mechanical Stretch Induces Hair Regeneration Through the Alternative Activation of Macrophages Nature Communications · 2019
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    6. M2 Macrophages Promote Wound-Induced Hair Neogenesis Journal of Dermatological Science · 2018
    7. Macrophages Promote Wound-Induced Hair Follicle Regeneration in a CX3CR1- and TGF-β1-Dependent Manner Journal of Investigative Dermatology · 2018
    8. Wound Regeneration Deficit in Rats Correlates with Low Morphogenetic Potential and Distinct Transcriptome Profile of Epidermis Journal of Investigative Dermatology · 2018
    9. Never Too Old to Regenerate? Wound-Induced Hair Follicle Neogenesis After Secondary Intention Healing in a Geriatric Patient Journal of Tissue Viability · 2018
    10. Dermal Blimp1 Acts Downstream of Epidermal TGFβ and Wnt/β-Catenin to Regulate Hair Follicle Formation and Growth Journal of Investigative Dermatology · 2017
    11. Targeting of CXXC5 by a Competing Peptide Stimulates Hair Regrowth and Wound-Induced Hair Neogenesis Journal of Investigative Dermatology · 2017
    12. Wounding Induces Dedifferentiation of Epidermal Gata6+ Cells and Acquisition of Stem Cell Properties Nature cell biology · 2017
    13. After Skin Wounding, Noncoding dsRNA Coordinates Prostaglandins and Wnts to Promote Regeneration Journal of Investigative Dermatology · 2017
    14. Macrophages Induce AKT/β-Catenin-Dependent Lgr5+ Stem Cell Activation and Hair Follicle Regeneration Through TNF Nature Communications · 2017
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    17. Interleukin-6 Null Mice Paradoxically Display Increased STAT3 Activity and Wound-Induced Hair Neogenesis Journal of Investigative Dermatology · 2016
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    19. Interleukin 6 and STAT3 Regulate p63 Isoform Expression in Keratinocytes During Regeneration Experimental Dermatology · 2015
    20. Fate of Prominin-1 Expressing Dermal Papilla Cells During Homeostasis, Wound Healing, and Wnt Activation Journal of Investigative Dermatology · 2015
    21. dsRNA Released by Tissue Damage Activates TLR3 to Drive Skin Regeneration Cell Stem Cell · 2015
    22. Lack of Collagen VI Promotes Wound-Induced Hair Growth Journal of Investigative Dermatology · 2015
    23. The Dermal Papilla: An Instructive Niche for Epithelial Stem and Progenitor Cells in Development and Regeneration of the Hair Follicle Cold Spring Harbor Perspectives in Medicine · 2014
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    25. Distinct Fibroblast Lineages Determine Dermal Architecture in Skin Development and Repair Nature · 2013
    26. Fgf9 From Dermal γδ T Cells Induces Hair Follicle Neogenesis After Wounding Nature Medicine · 2013
    27. Prostaglandin D2 Inhibits Wound-Induced Hair Follicle Neogenesis Through the Receptor Gpr44 Journal of Investigative Dermatology · 2012
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    30. Epithelial Wnt Ligand Secretion Is Required for Adult Hair Follicle Growth and Regeneration Journal of Investigative Dermatology · 2012
    31. Shh Maintains Dermal Papilla Identity and Hair Morphogenesis via a Noggin–Shh Regulatory Loop Genes & Development · 2012
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    3. Wound-Induced Hair Follicle Neogenesis: A New Perspective on Hair Follicle Regeneration in Adult Mammals PubMed · 2020
    4. Through the Lens of Hair Follicle Neogenesis: A New Focus on Mechanisms of Skin Regeneration After Wounding Seminars in Cell & Developmental Biology · 2019
    5. dsRNA Released by Tissue Damage Activates TLR3 to Drive Skin Regeneration Cell Stem Cell · 2015
    6. Epigenetic Control of Skin and Hair Regeneration After Wounding Experimental Dermatology · 2014
    7. A Model System to Analyze the Ability of Human Keratinocytes to Form Hair Follicles Experimental Dermatology · 2014
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