Wound Regeneration Deficit in Rats Correlates with Low Morphogenetic Potential and Distinct Transcriptome Profile of Epidermis

    January 2018 in “ Journal of Investigative Dermatology ”
    Christian F. Guerrero-Juarez, A. A. Astrowski, Rabi Murad, Christina T. Dang, V. O. Shatrova, A. B. Astrowskaja, Churlzu Lim, Raul Ramos, Xiaojie Wang, Yuchen Liu, Hye-Lim Lee, Kim Pham, Tsai-Ching Hsi, Ji Won Oh, Daniel E. Crocker, A Mortazavi, Mayumi Ito, Maksim V. Plikus
    Image of study
    TLDR Rats can't grow new hair follicles after skin wounds, unlike mice, due to differences in gene expression and response to WNT signaling.
    The study conducted on May 31, 2018, investigated the wound healing process in rats and mice, specifically focusing on hair follicle regeneration. The researchers found that rats, unlike mice, failed to regenerate new hair follicles after excisional wounding, despite complete re-epithelialization occurring within 25-33 days. This was observed across seven strains of rats. Transcriptome profiling revealed distinct gene expression patterns between rats and mice, suggesting that the wound epidermis in rats was less mature and less responsive to WNT signaling compared to mice. The study concluded that rats could serve as a suitable model for studying non-regenerative healing of large excisional skin wounds.
    Discuss this study in the Community →

    Research cited in this study

    19 / 19 results

    Related Community Posts Join

    6 / 1000+ results

      community Verteporfin day 119 update - donor hair regeneration human trial

      in Research/Science  148 upvotes 3 years ago
      A human trial of verteporfin, a drug that can inhibit wound healing by scarring and promote regeneration of original tissue and hair follicles to provide an unlimited source for hair transplants; people discussed the potential of this drug and how it could be rolled out in mainstream with more doctors getting on board.

      community How Does Exosome Therapy Work for Hair Loss?

      in Research/Science  5 upvotes 2 years ago
      Exosome hair therapy involves injecting stem cell-derived exosomes into the scalp to boost hair follicle regeneration and repair. Exosomes, which are not stem cells but products of them, contain bioactive chemicals and specific growth factors that promote new blood vessel formation, increase cell proliferation, reduce inflammation, and improve tissue repair, all crucial for hair health.

      community Verteporfin and Microneedling

      by nkrata in Treatments 1 year ago
      Clinical studies by Dr. Barghouthi and Dr. Bloxham indicate that Verteporfin, when used with FUE and FUT hair transplantation methods, shows promise in hair follicle regeneration and minimal scarring due to its ability to inhibit Yes-associated protein (YAP). Microneedling at depths of 3-3.5mm, combined with Verteporfin, could potentially reactivate dormant follicles, although the optimal dosage and application method are still under investigation. Concerns remain about the DHT sensitivity of regenerated follicles, highlighting the need for further research to optimize trauma levels and Verteporfin concentrations to achieve effective and scar-free hair regeneration.

    Related Research

    1 / 1 results