Wound Regeneration Deficit in Rats Correlates with Low Morphogenetic Potential and Distinct Transcriptome Profile of Epidermis

    January 2018 in “ Journal of Investigative Dermatology ”
    Christian F. Guerrero-Juarez, A. A. Astrowski, Rabi Murad … Maksim V. Plikus
    Studysummary This study found that large excisional wounds in rats across seven strains do not regenerate new hair follicles, unlike in mice, possibly due to differences in epidermal competence and transcriptional profiles.
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    Research cited in this study 20

    1. Targeting of CXXC5 by a Competing Peptide Stimulates Hair Regrowth and Wound-Induced Hair Neogenesis Journal of Investigative Dermatology · 2017
    2. Macrophages Induce AKT/β-Catenin-Dependent Lgr5+ Stem Cell Activation and Hair Follicle Regeneration Through TNF Nature Communications · 2017
    3. Msi2 Maintains Quiescent State of Hair Follicle Stem Cells by Directly Repressing the Hedgehog Signaling Pathway Journal of Investigative Dermatology · 2017
    4. Regeneration of Fat Cells from Myofibroblasts During Wound Healing Science · 2017
    5. Epidermal Notch1 Recruits RORγ+ Group 3 Innate Lymphoid Cells to Orchestrate Normal Skin Repair Nature Communications · 2016
    6. Interleukin 6 and STAT3 Regulate p63 Isoform Expression in Keratinocytes During Regeneration Experimental Dermatology · 2015
    7. dsRNA Released by Tissue Damage Activates TLR3 to Drive Skin Regeneration Cell Stem Cell · 2015
    8. Principles and Mechanisms of Regeneration in the Mouse Model for Wound-Induced Hair Follicle Neogenesis Regeneration · 2015
    9. Fgf9 From Dermal γδ T Cells Induces Hair Follicle Neogenesis After Wounding Nature Medicine · 2013
    10. Hopx Expression Defines a Subset of Multipotent Hair Follicle Stem Cells and a Progenitor Population Primed to Give Rise to K6+ Niche Cells Development · 2013
    11. Prostaglandin D2 Inhibits Wound-Induced Hair Follicle Neogenesis Through the Receptor Gpr44 Journal of Investigative Dermatology · 2012
    12. Skin Shedding and Tissue Regeneration in African Spiny Mice (Acomys) Nature · 2012
    13. Epithelial Wnt Ligand Secretion Is Required for Adult Hair Follicle Growth and Regeneration Journal of Investigative Dermatology · 2012
    14. P63 Regulates Satb1 to Control Tissue-Specific Chromatin Remodeling During Development of the Epidermis The Journal of Cell Biology · 2011
    15. Review of Hair Follicle Dermal Cells Journal of Dermatological Science · 2009
    16. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007
    17. Hair Follicle Regeneration Using Grafted Rodent and Human Cells Journal of Investigative Dermatology · 2007
    18. Cultured Peribulbar Dermal Sheath Cells Can Induce Hair Follicle Development and Contribute to the Dermal Sheath and Dermal Papilla Journal of Investigative Dermatology · 2003
    19. Induction of Follicle Formation and Hair Growth by Vibrissa Dermal Papillae Implanted into Rat Ear Wounds: Vibrissa-Type Fibres Are Specified Development · 1992
    20. The Formation of Vellus Hair Follicles from Human Adult Epidermis Journal of Investigative Dermatology · 1956

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