Cutaneous Retinoic Acid Levels Determine Hair Follicle Development And Downgrowth

    September 2012 in “ Journal of biological chemistry/˜The œJournal of biological chemistry ”
    Jun‐ichi Okano, Clara Levy, Ulrike Lichti … María I. Morasso
    Studysummary This study found that proper levels of retinoic acid, controlled by the enzyme Cyp26b1, are essential for normal hair follicle development and morphogenesis in mice.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on jbc.org →
    Discuss this study in the Community →

    Research cited in this study 19

    1. Dermal β-Catenin Activity in Response to Epidermal Wnt Ligands Is Required for Fibroblast Proliferation and Hair Follicle Initiation Development · 2012
    2. Endogenous Retinoids in the Hair Follicle and Sebaceous Gland Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · 2011
    3. Beta-Catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair Developmental Cell · 2010
    4. Review of Hair Follicle Dermal Cells Journal of Dermatological Science · 2009
    5. Epidermal Patterning and Induction of Different Hair Types During Mouse Embryonic Development Birth defects research · 2009
    6. Sox2-Positive Dermal Papilla Cells Specify Hair Follicle Type in Mammalian Epidermis Development · 2009
    7. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    8. Dlx3 Is a Crucial Regulator of Hair Follicle Differentiation and Cycling Development · 2008
    9. Wnt Signaling in Skin Organogenesis Organogenesis · 2008
    10. Genetic Basis of Skin Appendage Development Seminars in cell & developmental biology · 2007
    11. Dynamic Expression of Runx1 in Skin Affects Hair Structure Mechanisms of Development · 2006
    12. Molecular Dissection of Mesenchymal–Epithelial Interactions in the Hair Follicle PLoS biology · 2005
    13. Towards Dissecting the Pathogenesis of Retinoid-Induced Hair Loss: All-Trans Retinoic Acid Induces Premature Hair Follicle Regression by Upregulation of Transforming Growth Factor-β2 in the Dermal Papilla Journal of Investigative Dermatology · 2005
    14. BMP Signaling in the Control of Skin Development and Hair Follicle Growth Differentiation · 2004
    15. Stimulation of Ectodermal Organ Development by Ectodysplasin-A1 Developmental Biology · 2003
    16. Molecular Mechanisms Regulating Hair Follicle Development ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002
    17. Multiple Roles for Activated LEF/TCF Transcription Complexes During Hair Follicle Development and Differentiation Development · 1999
    18. Regulation of Human Dermal Papilla Cell Production of Insulin-Like Growth Factor Binding Protein-3 by Retinoic Acid, Glucocorticoids, and Insulin-Like Growth Factor-1 Journal of cellular physiology · 1996
    19. The Secret Life of the Hair Follicle Trends in genetics · 1992