Cutaneous Retinoic Acid Levels Determine Hair Follicle Development And Downgrowth
September 2012
in “
Journal of biological chemistry/The Journal of biological chemistry
”
retinoic acid RA Cyp26b1 hair follicle morphogenesis hair germ stage immunodeficient mice hair follicle development conditional deficiency dermis hair follicle density hair type hair bending regulators Wnt-catenin pathway transcription factors Runx Fox Sox hair follicle downgrowth hair follicle differentiation hair bending Wnt pathway
TLDR The right amount of retinoic acid is essential for normal hair growth and development.
The study concluded that cutaneous retinoic acid (RA) levels, regulated by the enzyme Cyp26b1, played a crucial role in hair follicle (hf) development and downgrowth in mice. Elevated RA levels due to Cyp26b1 deficiency led to significant hair follicle defects, including arrested growth at the hair germ stage and decreased hair follicle density. Normalizing RA levels through skin grafting restored hf development. The study identified that RA influenced the Wnt-catenin pathway and various transcription factors, establishing RA's essential role in hf morphogenesis and differentiation. These findings highlighted the importance of precise RA regulation for normal hair follicle formation and function, suggesting potential therapeutic targets for hair growth disorders.
