Cutaneous Retinoic Acid Levels Determine Hair Follicle Development And Downgrowth

    September 2012 in “ Journal of biological chemistry/˜The œJournal of biological chemistry ”
    Jun‐ichi Okano, Clara Levy, Ulrike Lichti, Hongwei Sun, Stuart H. Yuspa, Yasuo Sakai, María I. Morasso
    TLDR The right amount of retinoic acid is essential for normal hair growth and development.
    The study concluded that cutaneous retinoic acid (RA) levels, regulated by the enzyme Cyp26b1, played a crucial role in hair follicle (hf) development and downgrowth in mice. Elevated RA levels due to Cyp26b1 deficiency led to significant hair follicle defects, including arrested growth at the hair germ stage and decreased hair follicle density. Normalizing RA levels through skin grafting restored hf development. The study identified that RA influenced the Wnt-catenin pathway and various transcription factors, establishing RA's essential role in hf morphogenesis and differentiation. These findings highlighted the importance of precise RA regulation for normal hair follicle formation and function, suggesting potential therapeutic targets for hair growth disorders.
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      in Minoxidil  6 upvotes 3 months ago
      Topical minoxidil with retinoic acid is effective but causes scalp irritation, leading the user to consider switching to 2.5mg oral minoxidil. Oral minoxidil may cause body hair growth and heart-related side effects, so it's advised to use it under medical guidance.

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      in Minoxidil  317 upvotes 3 months ago
      Minoxidil is more effective when combined with retinoic acid, such as tretinoin or tazarotene, enhancing hair growth. Some users experience significant regrowth, while others see minimal effects or side effects.

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      in Treatment  4 upvotes 10 months ago
      The conversation is about using a topical serum for hair loss with ingredients like finasteride and minoxidil, and the option to exclude retinoic acid and hydrocortisone due to concerns about long-term effects. One user prefers using only finasteride, avoiding minoxidil and retinoic acid, and plans to remove hydrocortisone in future orders.

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