TLDR Hair, teeth, and mammary glands develop similarly at first but use different genes later.
The development of hair follicles, teeth, and mammary glands relied on epithelial-mesenchymal interactions and conserved signalling molecules. Early stages of these skin appendages were similar, starting with the formation of a placode that invaginated to form a bud. These stages required the same genes and signalling pathways, leading to similar phenotypes when altered. Post-bud stage, each organ exhibited unique epithelial growth patterns, using more specific genes.
479 citations,
January 2005 in “BioEssays” Hair follicle development is controlled by interactions between skin tissues and specific molecular signals.
66 citations,
June 2004 in “Development” FGF signaling is crucial for starting feather development in chicken embryos.
81 citations,
January 2003 in “The FASEB Journal” Follistatin helps hair growth and cycling, while activin prevents it.
854 citations,
February 2002 in “The journal of investigative dermatology/Journal of investigative dermatology” Understanding hair follicle development can help treat hair loss, skin regeneration, and certain skin cancers.
165 citations,
September 2001 in “Genes & development” CDP is crucial for lung and hair follicle cell development.
694 citations,
April 2000 in “Nature genetics” Msx2 deficiency in mice leads to bone growth and organ development problems.
854 citations,
February 2002 in “The journal of investigative dermatology/Journal of investigative dermatology” Understanding hair follicle development can help treat hair loss, skin regeneration, and certain skin cancers.
43 citations,
March 2009 in “Journal of Cellular and Molecular Medicine” TGF-β2 plays a key role in human hair growth and development.
82 citations,
February 2017 in “Cold Spring Harbor Perspectives in Biology” The TGF-β family helps control how cells change and move, affecting skin, hair, and organ development.
22 citations,
March 2021 in “Materials Today Bio” Scaffold-based strategies show promise for regenerating hair follicles and teeth but need more research for clinical use.
3 citations,
August 2023 in “Genes” The document concludes that various signaling pathways and genetic factors are crucial for chicken feather development, affecting poultry quality.
