Genetic Basis of Skin Appendage Development

January 2007 in “ Seminars in cell & developmental biology ”

Marja L. Mikkola

hair follicles epithelial-mesenchymal interactions signalling molecules placode epithelial growth patterns genes signalling pathways

TLDR Hair, teeth, and mammary glands develop similarly at first but use different genes later.

The development of hair follicles, teeth, and mammary glands relied on epithelial-mesenchymal interactions and conserved signalling molecules. Early stages of these skin appendages were similar, starting with the formation of a placode that invaginated to form a bud. These stages required the same genes and signalling pathways, leading to similar phenotypes when altered. Post-bud stage, each organ exhibited unique epithelial growth patterns, using more specific genes.

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Genetic Basis of Skin Appendage Development

Research cited in this study

research Adenomatous Polyposis Coli (APC) Is Required for Normal Development of Skin and Thymus

research Molecular Principles of Hair Follicle Induction and Morphogenesis

research Canonical WNT Signaling Promotes Mammary Placode Development and Is Essential for Initiation of Mammary Gland Morphogenesis

research FGF Signaling Is Required for Initiation of Feather Placode Development

research Defining BMP Functions in the Hair Follicle by Conditional Ablation of BMP Receptor IA

research Stimulation of Ectodermal Organ Development by Ectodysplasin-A1

research Control of Pelage Hair Follicle Development and Cycling by Complex Interactions Between Follistatin and Activin

research Molecular Mechanisms Regulating Hair Follicle Development

research The Transcriptional Repressor CDP (Cutl1) Is Essential for Epithelial Cell Differentiation of the Lung and the Hair Follicle

research Edar/Eda Interactions Regulate Enamel Knot Formation in Tooth Morphogenesis

research Msx2 Deficiency in Mice Causes Pleiotropic Defects in Bone Growth and Ectodermal Organ Formation

Related Community Posts Join

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Microneedling and aloe vera to recruit stem cells.

community Finasteride only reduces scalp DHT by ~40%. Why does it work?

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