TLDR FGF signaling is crucial for starting feather development in chicken embryos.
The study concluded that FGF signaling was essential for the initiation of feather placode development. This was demonstrated through experiments where ppf explants were cultured with 25 μM Su5402, an inhibitor of FGF signaling, which resulted in the absence of detectable di-phosphorylation of ERK1 and ERK2. This indicated that the concentration of Su5402 used was sufficient to block FGF signaling in vitro, thereby confirming the necessity of FGF signaling in the early stages of feather development.
854 citations
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February 2002 in “The journal of investigative dermatology/Journal of investigative dermatology” Understanding hair follicle development can help treat hair loss, skin regeneration, and certain skin cancers.
160 citations
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January 2014 in “Seminars in cell & developmental biology” Early development of hair, teeth, and glands involves specific signaling pathways and cellular interactions.
133 citations
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February 2019 in “PLoS Biology” Feather patterns in birds are shaped by signaling interactions and cell movements, with EDA/EDAR crucial for pattern formation.
10 citations
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March 2016 in “Development Growth & Differentiation” Scientists created feather buds in lab-grown chick skin using specific cell interactions.
3 citations
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August 2023 in “Genes” The document concludes that various signaling pathways and genetic factors are crucial for chicken feather development, affecting poultry quality.
85 citations
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October 2006 in “Current opinion in cell biology” Feather growth and regeneration involve complex patterns, stem cells, and evolutionary insights.
