Molecular Regulatory Mechanisms in Chicken Feather Follicle Morphogenesis

August 2023 in “ Genes ”

Gaige Ji, Ming Zhang, Yan Tu, Yifan Liu, Yanju Shan, Xiaojun Ju, Jianmin Zou, Shu JingTing, Zhongwei Sheng, Hua Li

Wnt Eda EGF FGF BMP Shh Notch miRNAs lncRNAs gga-miR-10b-3p gga-miR-204 lnc5351 lnc7349

Studysummary This review summarizes current research on molecular pathways, such as Wnt and Notch, that regulate feather follicle development in yellow-feathered broilers, highlighting their potential impact on poultry carcass quality and suggesting areas for future study.

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The review "Molecular Regulatory Mechanisms in Chicken Feather Follicle Morphogenesis" delves into the intricate signaling pathways and genetic elements involved in the development of feather follicles in chickens. Key pathways such as Wnt, Eda, EGF, FGF, BMP, Shh, and Notch are crucial for various stages of feather formation, influencing cell proliferation, differentiation, and migration. The study emphasizes the significant roles of non-coding RNAs, including miRNAs and lncRNAs, in regulating feather growth and morphogenesis. Specific miRNAs like gga-miR-10b-3p and gga-miR-204, and lncRNAs such as lnc5351 and lnc7349, are highlighted for their roles in feather placode development and Wnt signaling pathways. The findings provide a comprehensive understanding of the molecular mechanisms underlying feather development, with potential implications for poultry breeding and biotechnology.

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