Suppression of Wnt/β-Catenin Signaling by EGF Receptor Is Required for Hair Follicle Development
September 2018
in “
Molecular Biology of the Cell
”
Wnt/β-catenin signaling Epidermal Growth Factor Receptor EGFR hair follicle development kinase activity Wnt gene transcription β-catenin signaling hair follicle defects proliferation apoptosis keratinocytes Wnt antagonist sFRP1 autocrine loops Wnt signaling hair growth cell proliferation cell death skin cells Wnt blocker secreted frizzled-related protein 1
Studysummary This study found that in mice lacking EGFR, elevated Wnt signaling disrupts hair follicle development by affecting cell proliferation and differentiation, revealing a critical role for EGFR in regulating these processes.
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