Recent Advances in the Epidermal Growth Factor Receptor/Ligand System Biology on Skin Homeostasis and Keratinocyte Stem Cell Regulation

June 2013 in “ Journal of Dermatological Science ”

Daisuke Nanba, Fujio Toki, Yann Barrandon, Shigeki Higashiyama

epidermal growth factor EGF receptor EGFR keratinocyte stem cell EGFR inhibitors skin homeostasis hair follicle homeostasis regenerative medicine

TLDR Understanding EGFR's role in skin is crucial for better treatments and managing side effects.

The document discussed the role of the epidermal growth factor (EGF) receptor/ligand system in skin homeostasis and keratinocyte stem cell regulation. It highlighted that aberrant activation of EGF receptor (EGFR) signaling was linked to tumor cells, and while EGFR inhibitors were used clinically, they caused skin toxicities such as rashes, dryness, and hair abnormalities. These side effects underscored the importance of EGFR in maintaining skin and hair follicle homeostasis. The study emphasized the significance of understanding EGFR's role in skin biology to improve treatments for skin disorders and manage EGFR inhibitor-related toxicities. Additionally, modulating the EGF receptor/ligand system was seen as promising for advances in regenerative medicine for the skin.

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