The Cutaneous Epidermal Growth Factor Network: Can It Be Translated Clinically to Stimulate Hair Growth?

The study investigated the role of the epidermal growth factor receptor (EGFR) network in hair follicle biology and its potential to stimulate hair growth. It found that EGFR is crucial for hair growth, with its inhibition sometimes promoting hair growth, as observed in cancer patients using EGFR inhibitors. The research suggested that manipulating EGFR signaling could offer new strategies for managing hair loss, particularly by promoting the transition to the anagen phase of the hair cycle. The study also highlighted the promise of EGFR inhibitors like anthralin in treating alopecia areata, with a 56.2% complete response rate, and the potential for topical EGFR blockers to induce long-term hair growth. However, it emphasized the need for further research to fully understand EGF interactions and avoid adverse effects like secondary alopecia.