Non-Rash Skin Toxicities Associated with Novel Targeted Therapies

The document from 2006 discusses the emergence of novel targeted therapies for cancer and the associated non-rash skin toxicities that often lead to treatment delays or discontinuation. These toxicities include skin hyperpigmentation, xerosis (dry skin), pruritus (itching), changes in hair growth and color, alterations in nails and the area around them, and hand-foot skin reactions. The review emphasizes the importance of early recognition and diagnosis of these side effects to allow for prompt treatment or adjustment of the therapy dosage. It provides an overview of the dermatologic toxicities seen with these agents and offers guidelines for their management.