Non-Rash Skin Toxicities Associated with Novel Targeted Therapies

December 2006 in “ Clinical lung cancer ”

Mario E. Lacouture, Scott A. Boerner, Patricia LoRusso

skin hyperpigmentation xerosis pruritus changes in hair growth changes in hair color alterations in nails hand-foot skin reactions dry skin itching

Studysummary This review outlines various non-rash skin toxicities associated with novel targeted anticancer therapies and provides guidelines for their early diagnosis and management, but reports no new clinical results.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The document from 2006 discusses the emergence of novel targeted therapies for cancer and the associated non-rash skin toxicities that often lead to treatment delays or discontinuation. These toxicities include skin hyperpigmentation, xerosis (dry skin), pruritus (itching), changes in hair growth and color, alterations in nails and the area around them, and hand-foot skin reactions. The review emphasizes the importance of early recognition and diagnosis of these side effects to allow for prompt treatment or adjustment of the therapy dosage. It provides an overview of the dermatologic toxicities seen with these agents and offers guidelines for their management.

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