TLDR EGFR inhibitors can cause various skin issues during cancer treatment, and managing these is important for patient care.
The document discussed the overexpression of the epidermal growth factor receptor (EGFR) in various cancers and the use of EGFR inhibitors in their treatment. It highlighted that skin lesions during cancer treatment could result from various factors, including specific drugs and therapies. The exact mechanism of skin toxicity from EGFR inhibitors was not well understood but was linked to the modification of the RAS/RAF/MEK/ERK signaling pathway. Common side effects included pruritus, xerosis, papulopustular rash, hand-foot skin reaction, alopecia, hair dystrophy, and paronychia. The document provided options for preventing and managing these adverse events, which are crucial for patient care during oncological treatment.
149 citations,
January 2015 in “Journal of the American Academy of Dermatology” Targeted cancer therapies often cause skin side effects, needing dermatologist care.
192 citations,
January 2015 in “Journal of the American Academy of Dermatology” Targeted cancer therapies often cause serious skin problems that need careful management.
88 citations,
July 2014 in “Journal of the American Academy of Dermatology” Targeted cancer therapies often cause skin reactions, so dermatologists must manage these effects.
68 citations,
January 2014 in “Dermatology research and practice” Skin side effects from cancer drugs targeting EGFR can affect treatment adherence but can be managed with antibiotics like tetracycline.
87 citations,
March 2013 in “Expert Review of Anticancer Therapy” Afatinib often causes skin problems that need proactive management.
138 citations,
February 2007 in “European journal of cancer” EGFR inhibitors often cause skin problems and other side effects, but these are usually reversible and can be managed to keep patients comfortable.
38 citations,
February 2012 in “Supportive Care in Cancer” Skin problems like acne, dry skin, and nail and hair changes are common in patients taking EGFR inhibitors.
192 citations,
January 2015 in “Journal of the American Academy of Dermatology” Targeted cancer therapies often cause serious skin problems that need careful management.
15 citations,
February 2017 in “Nursing Clinics of North America” Targeted cancer therapies can cause skin side effects, which should be treated early to help patients' quality of life and treatment adherence.
Modern skin cancer treatments can cause skin side effects and hair loss, affecting patients' quality of life.
68 citations,
January 2014 in “Dermatology research and practice” Skin side effects from cancer drugs targeting EGFR can affect treatment adherence but can be managed with antibiotics like tetracycline.
