Cutaneous Adverse Effects of Targeted Therapies

January 2015 in “ Journal of the American Academy of Dermatology ”

James B. Macdonald, Brooke Macdonald, Loren E. Golitz, Patricia LoRusso, Aleksandar Sekulić

cutaneous adverse effects targeted therapies metastatic melanoma basal cell carcinoma PI3K-AKT-mTOR pathway RAS-RAF-MEK-ERK pathway skin toxicities hedgehog signaling pathway inhibitors immunotherapies dermatologic side effects skin side effects skin cancer treatments

TLDR Targeted cancer therapies often cause skin side effects, needing dermatologist care.

The document discusses the emergence of targeted therapies for skin cancers like metastatic melanoma and basal cell carcinoma, focusing on the cutaneous adverse effects associated with these treatments. It highlights that inhibitors targeting the PI3K-AKT-mTOR and RAS-RAF-MEK-ERK pathways, which are implicated in various cancers, frequently cause skin toxicities. The document also mentions hedgehog signaling pathway inhibitors and immunotherapies as having similar dermatologic side effects. It emphasizes the importance of dermatologists in managing these skin-related issues, given the increasing use of these targeted therapies. The article is part of a continuing medical education series and aims to educate on the skin toxicities, their prevalence, and the clinical significance of both on-target and off-target effects of these cancer treatments.

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Research cited in this study

4 / 4 results

research Cutaneous Manifestations of Dabrafenib: A Selective Inhibitor of Mutant BRAF in Patients with Metastatic Melanoma

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Cutaneous Adverse Effects of Targeted Therapies

Research cited in this study

research Cutaneous Manifestations of Dabrafenib: A Selective Inhibitor of Mutant BRAF in Patients with Metastatic Melanoma

research Advances in the Management of Cutaneous Toxicities of Targeted Therapies

research A Randomized Trial of Minoxidil in Chemotherapy-Induced Alopecia

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