TLDR Targeted cancer therapies often cause skin side effects, needing dermatologist care.
The document discusses the emergence of targeted therapies for skin cancers like metastatic melanoma and basal cell carcinoma, focusing on the cutaneous adverse effects associated with these treatments. It highlights that inhibitors targeting the PI3K-AKT-mTOR and RAS-RAF-MEK-ERK pathways, which are implicated in various cancers, frequently cause skin toxicities. The document also mentions hedgehog signaling pathway inhibitors and immunotherapies as having similar dermatologic side effects. It emphasizes the importance of dermatologists in managing these skin-related issues, given the increasing use of these targeted therapies. The article is part of a continuing medical education series and aims to educate on the skin toxicities, their prevalence, and the clinical significance of both on-target and off-target effects of these cancer treatments.
173 citations
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July 2012 in “British Journal of Dermatology” Dabrafenib can cause skin growths and sometimes low-grade skin cancer.
42 citations
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April 2012 in “Seminars in Oncology” Targeted cancer therapies often cause skin problems that need careful management to improve patient quality of life and treatment success.
127 citations
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July 1996 in “Journal of The American Academy of Dermatology” Minoxidil shortens baldness from chemotherapy by 50.2 days without significant side effects.
49 citations
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October 1994 in “Annals of Oncology” Minoxidil not effective in preventing chemotherapy-induced hair loss.
4 citations
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January 2016 in “Dermatology Review” Cancer treatments often cause skin, nail, and hair problems.
Modern skin cancer treatments can cause skin side effects and hair loss, affecting patients' quality of life.
1 citations
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March 2019 in “Actas Dermo-Sifiliográficas” New cancer treatments are less harmful to hair but can still cause hair loss, color, shape, and growth changes.
26 citations
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August 2018 in “American Journal of Clinical Dermatology” Hair loss in cancer patients can be related to the cancer itself, treatment, or other conditions, and understanding it is important for diagnosis and patient care.
3 citations
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November 2018 in “Oncology issues” Cancer survivors often experience worse skin problems from treatment than expected, and working with dermatologists could help improve their condition.
