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    Glossary Hedgehog Pathway Inhibitors

    drugs that block cell growth signals to treat cancer

    Hedgehog Pathway Inhibitors are drugs that block the Hedgehog signaling pathway, which is crucial for cell growth and differentiation during embryonic development. In adults, abnormal activation of this pathway can lead to cancers such as basal cell carcinoma. By inhibiting this pathway, these drugs can help treat certain types of cancer by preventing the uncontrolled growth of cancer cells.

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    1. Roles of the Hedgehog Signaling Pathway in Cutaneous Physiology and Oncology International journal of dermatology and venereology · 2019
    2. From basal cell carcinoma morphogenesis to the alopecia induced by hedgehog inhibitors: connecting the dots British Journal of Dermatology · 2017 · 17 citations
    3. Basal Cell Carcinoma, Hedgehog Signaling, and Targeted Therapeutics: The Long and Winding Road Journal of Investigative Dermatology · 2014 · 15 citations
    4. WISP-1 induced by mechanical stress contributes to fibrosis and hypertrophy of the ligamentum flavum through Hedgehog-Gli1 signaling Experimental & Molecular Medicine · 2021 · 36 citations
    5. Dermal T cell immunity and key regulatory signaling pathways: Implications in immune-mediated alopecia and hair regeneration Genes & Diseases · 2025 · 1 citations
    6. Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK / STAT1 signaling pathway FEBS Open Bio · 2025
    7. Aberrant Wnt Signaling Induces Comedo-Like Changes in the Murine Upper Hair Follicle 2021 · 4 citations
    8. Targeting Superficial or Nodular Basal Cell Carcinoma with Topically Formulated Small Molecule Inhibitor of Smoothened Clinical cancer research · 2011 · 63 citations
    9. Vitamin E promotes dermal papilla cell proliferation via the lncRNA2919/STAT1 axis to activate the Hedgehog signaling pathway Non-coding RNA Research · 2026
    10. Hedgehog Pathway Inhibitors against Tumor Microenvironment Cells · 2021 · 21 citations
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