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    Glossary Hedgehog Pathway Inhibitors

    drugs that block cell growth signals to treat cancer

    Hedgehog Pathway Inhibitors are drugs that block the Hedgehog signaling pathway, which is crucial for cell growth and differentiation during embryonic development. In adults, abnormal activation of this pathway can lead to cancers such as basal cell carcinoma. By inhibiting this pathway, these drugs can help treat certain types of cancer by preventing the uncontrolled growth of cancer cells.

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    1. Phase I Study of the Hedgehog Pathway Inhibitor IPI-926 in Adult Patients with Solid Tumors Clinical Cancer Research · 2013 · 136 citations
    2. Characterization and Management of Hedgehog Pathway Inhibitor-Related Adverse Events in Patients With Advanced Basal Cell Carcinoma ˜The œoncologist · 2016 · 127 citations
    3. Hedgehog Pathway Inhibitors against Tumor Microenvironment Cells · 2021 · 21 citations
    4. Evaluation of the Tolerability of Hedgehog Pathway Inhibitors in the Treatment of Advanced Basal Cell Carcinoma: A Narrative Review of Treatment Strategies American Journal of Clinical Dermatology · 2024 · 10 citations
    5. Aberrant Activation of the Hedgehog Pathway in Cutaneous Melanoma: Therapeutic Potential of Pharmacological Inhibitors International Journal of Molecular Sciences · 2026
    6. A Review of Hedgehog Inhibitors Sonidegib and Vismodegib for Treatment of Advanced Basal Cell Carcinoma Journal of drugs in dermatology · 2021 · 25 citations
    7. From basal cell carcinoma morphogenesis to the alopecia induced by hedgehog inhibitors: connecting the dots British Journal of Dermatology · 2017 · 17 citations
    8. Hair loss and Hedgehog inhibitors: a class effect? British Journal of Dermatology · 2014 · 9 citations
    9. The HEDGEHOG-GLI1 pathway is important for fibroproliferative properties in keloids and as a candidate therapeutic target Communications biology · 2023
    10. 139 Anti-BCC efficacy of a topical hedgehog inhibitor without adverse effects in BCNS patients in a phase 2 randomized controlled trial 2018 · 1 citations
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    Community 1 of 4

    1. Physio-metabolic method (antiandrogen, minoxidil, leg training and cold) Community · 7 Jun 2024
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