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    Glossary Hedgehog Pathway Inhibitors

    drugs that block cell growth signals to treat cancer

    Hedgehog Pathway Inhibitors are drugs that block the Hedgehog signaling pathway, which is crucial for cell growth and differentiation during embryonic development. In adults, abnormal activation of this pathway can lead to cancers such as basal cell carcinoma. By inhibiting this pathway, these drugs can help treat certain types of cancer by preventing the uncontrolled growth of cancer cells.

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    1. Phase I Study of the Hedgehog Pathway Inhibitor IPI-926 in Adult Patients with Solid Tumors Clinical Cancer Research · 2013 · 136 citations
    2. Characterization and Management of Hedgehog Pathway Inhibitor-Related Adverse Events in Patients With Advanced Basal Cell Carcinoma ˜The œoncologist · 2016 · 127 citations
    3. Hedgehog Pathway Inhibitors against Tumor Microenvironment Cells · 2021 · 21 citations
    4. Evaluation of the Tolerability of Hedgehog Pathway Inhibitors in the Treatment of Advanced Basal Cell Carcinoma: A Narrative Review of Treatment Strategies American Journal of Clinical Dermatology · 2024 · 10 citations
    5. Aberrant Activation of the Hedgehog Pathway in Cutaneous Melanoma: Therapeutic Potential of Pharmacological Inhibitors International Journal of Molecular Sciences · 2026
    6. A Review of Hedgehog Inhibitors Sonidegib and Vismodegib for Treatment of Advanced Basal Cell Carcinoma Journal of drugs in dermatology · 2021 · 25 citations
    7. From basal cell carcinoma morphogenesis to the alopecia induced by hedgehog inhibitors: connecting the dots British Journal of Dermatology · 2017 · 17 citations
    8. Hair loss and Hedgehog inhibitors: a class effect? British Journal of Dermatology · 2014 · 9 citations
    9. The HEDGEHOG-GLI1 pathway is important for fibroproliferative properties in keloids and as a candidate therapeutic target Communications biology · 2023
    10. 139 Anti-BCC efficacy of a topical hedgehog inhibitor without adverse effects in BCNS patients in a phase 2 randomized controlled trial 2018 · 1 citations
    11. Roles of the Hedgehog Signaling Pathway in Cutaneous Physiology and Oncology International journal of dermatology and venereology · 2019
    12. WISP-1 induced by mechanical stress contributes to fibrosis and hypertrophy of the ligamentum flavum through Hedgehog-Gli1 signaling Experimental & Molecular Medicine · 2021 · 36 citations
    13. Basal Cell Carcinoma, Hedgehog Signaling, and Targeted Therapeutics: The Long and Winding Road Journal of Investigative Dermatology · 2014 · 15 citations
    14. Dermal T cell immunity and key regulatory signaling pathways: Implications in immune-mediated alopecia and hair regeneration Genes & Diseases · 2025 · 1 citations
    15. Targeting Superficial or Nodular Basal Cell Carcinoma with Topically Formulated Small Molecule Inhibitor of Smoothened Clinical cancer research · 2011 · 63 citations
    16. Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK / STAT1 signaling pathway FEBS Open Bio · 2025
    17. Non-surgical treatments for basal cell skin cancer Vestnik dermatologii i venerologii · 2021 · 4 citations
    18. Aberrant Wnt Signaling Induces Comedo-Like Changes in the Murine Upper Hair Follicle 2021 · 4 citations
    19. Drug-induced scarring and permanent alopecia JAAD reviews. · 2024 · 2 citations
    20. Disproportionality analysis comparing safety profiles of sonidegib and vismodegib based on the FAERS database Scientific Reports · 2025 · 1 citations
    21. Understanding Cancer Cells of Origin in Cutaneous Tumors Elsevier eBooks · 2016 · 1 citations
    22. Dermatopathology Update Actas Dermo-Sifiliográficas · 2013
    23. Oncogenes and morphogens: intricacies of targeted therapy in cutaneous basal cell carcinoma British Journal of Dermatology · 2017
    24. Dermatologic adverse events associated with chemotherapy and targeted anticancer therapy Dermatology Review · 2016 · 4 citations
    25. A Sonidegib Experience in the Treatment of Basal Cell Carcinoma with Systemic Lupus Erythematosus: A Case Report Clinical Cosmetic and Investigational Dermatology · 2025
    26. Trichoscopy and LC-OCT findings in sonidegib-induced alopecia in patients with advanced basal cell carcinoma Dermatology Reports · 2024
    27. Chemotherapy-Induced Hair Loss: The Use of Biomarkers for Predicting Alopecic Severity and Treatment Efficacy Biomarker Insights · 2019 · 10 citations
    28. Cutaneous adverse effects of targeted therapies Journal of the American Academy of Dermatology · 2015 · 149 citations
    29. 085 Dermal papilla cells control hair follicle matrix keratinocytes proliferation through versican Journal of Investigative Dermatology · 2024
    30. Management of Dermatologic Toxicities Journal of the National Comprehensive Cancer Network · 2015 · 12 citations