Aberrant Wnt Signaling Induces Comedo-Like Changes in the Murine Upper Hair Follicle

    December 2021 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    Wei Shang, Alvin Yong Quan Tan, Maurice A. M. Van Steensel, Xinhong Lim
    Image of study
    TLDR Overactive Wnt signaling in mouse skin stem cells causes acne-like cysts and shrinking oil glands, which some treatments can partially fix.
    The study investigates the effects of aberrant Wnt signaling on the upper hair follicle (HF) and sebaceous gland (SG) in mice, revealing that persistent activation of Wnt signaling leads to the formation of junctional zone (JZ) cysts resembling human acne comedones and causes sebaceous gland atrophy. Conversely, loss of Wnt signaling results in the enlargement of the JZ, infundibulum, and sebaceous glands. Treatments with all-trans retinoic acid (atRA) and Hedgehog signaling inhibitors partially mitigated these effects. The findings suggest that imbalances in Wnt signaling can induce pathologies similar to human acne, highlighting potential therapeutic targets. The study included data from 3-6 mice per group.
    Discuss this study in the Community →

    Research cited in this study

    14 / 14 results

    Related Community Posts Join

    6 / 101 results

      community Better Than Minoxidil? Topical Sodium Valproate

      in Research/Science  50 upvotes 9 months ago
      Topical sodium valproate may promote hair growth by inhibiting GSK3β, allowing beta-catenin to proliferate, but it has potential side effects and requires more research. The conversation also mentions skepticism about a product called Vdphlo1, which includes sodium valproate and other ingredients.

      community Hair follicle neogenesis

       6 upvotes 10 years ago
      A user plans to experiment with creating new hair follicles using methods like derma rolling, applying lithium chloride, tannic acid, and various other substances including caffeine, ketoconazole, and raspberry ketones. They also consider using anti-inflammatories, immunosuppressants, and DHT inhibitors to potentially improve results.

    Related Research

    3 / 3 results