Homeostasis of the Sebaceous Gland and Mechanisms of Acne Pathogenesis

Innate lymphoid cells help control skin bacteria by regulating sebaceous glands.

Antibiotics can reduce acne but may lead to resistant bacteria, and understanding the skin's bacteria is important for treatment.

Male hormones and their receptors play a key role in hair loss and skin health, with potential new treatments being explored.

New anti-acne medications are being tested to offer alternatives to current treatments.

Male pattern baldness involves genetics, hormones, and needs better treatments.

Genetic changes in mice help understand skin and hair disorders, aiding treatment development for acne and hair loss.

Activating β-catenin in different skin stem cells causes various types of hair growth and skin tumors.

Sebaceous lipids are crucial for keeping skin and eyes healthy in mice.

Sebaceous glands in male pattern hair loss patients have more lobules and might cause early hair growth phase shifts.

Androgen receptor activity blocks Wnt/β-catenin signaling, affecting hair growth and skin cell balance.

The best way to treat acne is to prevent healthy skin glands from turning into acne lesions by controlling the triggers early on.

BLIMP1 is essential for skin maintenance but not for defining sebaceous gland progenitors.

Wnt signaling controls whether hair follicle stem cells stay inactive or regenerate hair.

The guide explains how to study human and mouse sebaceous glands using various staining and imaging techniques, and emphasizes the need for standardized assessment methods.

EGFR hyperactivation increases sebaceous gland size and sebum production in mice.

Indian Hedgehog helps control skin cell growth and protects against aggressive skin cancer.

Understanding EGFR's role in skin is crucial for better treatments and managing side effects.

The balance between androgen receptor and p53 is crucial for sebaceous gland differentiation.

The document concludes that understanding the sebaceous gland's development and function is key to addressing related skin diseases and aging effects.

Testosterone's muscle-building effects do not require its conversion to DHT.

Maintaining the right amount of retinoic acid is crucial for healthy hair and skin.

Free fatty acids in sebum boost skin's defense against acne by increasing antimicrobial peptides.

Lrig1 marks a unique group of stem cells in mouse skin that can become different skin cell types.

Anti-acne medications may work by reducing the activity of a protein involved in acne development.

Retinoic acid-binding proteins in skin are regulated by β-catenin and Notch signalling.

Neuregulin3 affects cell development in the skin and mammary glands.

Fgfr2b helps maintain healthy skin and prevent cancer.

Temporary activation of β-catenin can create new hair follicles, but ongoing activation is needed to keep hair follicle tumors.

Stem cell behavior varies with stimuli, and lineage changes can happen without affecting stem cell division.

Estrogen Receptor ß (ERß) is the main hormone controller in human skin and hair follicles, not Estrogen Receptor α (ERα) or the Androgen Receptor (AR).

Overexpression of ΔNLef1 in mouse skin leads to hair loss, cysts, and skin tumors.

Tcf3 and Lef1 are key in deciding skin stem cell roles.

Sebocytes play a key role in controlling androgen levels in human skin.

Hormone treatments in transsexual individuals reduce hair growth and oil production in male-to-females and increase them in female-to-males.

The absence of functional sebaceous glands causes hair follicle destruction and scarring alopecia.

Estrogen and progesterone don't directly affect hair growth in androgenic alopecia and alopecia areata.

ErbB2 signaling is crucial for skin cell growth and cancer development in mice.

RXR-alpha is strongly expressed in both normal and psoriatic skin and may help in skin cell differentiation and hair growth.

The understanding of male-pattern baldness remains unclear.