Ligand-Independent Epidermal Growth Factor Receptor Hyperactivation Increases Sebaceous Gland Size and Sebum Secretion in Mice

    August 2013 in “ Experimental Dermatology ”
    Maik Dahlhoff, Martin Hrabě de Angelis, Eckhard Wolf, Marlon R. Schneider
    Studysummary In this study, the researchers found that constitutive activation of the EGFR in mice led to increased sebum production, enlarged sebaceous glands, and altered gene expression related to sebocyte proliferation and lipogenesis.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on onlinelibrary.wiley.com →
    Discuss this study in the Community →

    Research cited in this study 8

    1. Development and Homeostasis of the Sebaceous Gland Seminars in Cell & Developmental Biology · 2012
    2. Epigen Transgenic Mice Develop Enlarged Sebaceous Glands Journal of Investigative Dermatology · 2009
    3. New Developments in Our Understanding of Acne Pathogenesis and Treatment Experimental dermatology · 2009
    4. Beyond Wavy Hairs: The Role of EGFR in Skin and Hair Biology American Journal Of Pathology · 2008
    5. Deregulated Expression of c-Myc Depletes Epidermal Stem Cells Nature Genetics · 2001
    6. C-Myc Activation in Transgenic Mouse Epidermis Results in Mobilization of Stem Cells and Differentiation of Their Progeny Current Biology · 2001
    7. The Human Sebocyte Culture Model Provides New Insights Into Development and Management of Seborrhoea and Acne Dermatology · 1998
    8. Comparison of Epidermal Growth Factor Binding and Receptor Distribution in Normal Human Epidermis and Epidermal Appendages Journal of Investigative Dermatology · 1984

    Related research 4

    1. Culture of the Human Pilosebaceous Unit, Hair Follicle, and Sebaceous Gland Experimental Dermatology · 2018
    2. The Effect of Flavonoids on Regenerated Hair Follicles with Pigmentation Journal of Dermatological Science · 2017
    3. The Organ-Maintained Human Sebaceous Gland Dermatology · 1998
    4. Histomorphological Studies on the Skin of Camel (Camelus Dromedarius) in Bangladesh Bangladesh Journal of Animal Science · 1992