The Organ-Maintained Human Sebaceous Gland

    January 1998 in “ Dermatology ”
    Robert Guy, Terence Kealey
    TLDR Human sebaceous glands can grow normally for a week without certain growth factors, and adding estrogen reduces their oil production without affecting cell growth.
    The study found that human sebaceous glands maintained in a medium without epidermal growth factor (EGF) and phenol red showed in vivo rates of cell division and lipogenesis, as well as preserved morphology, over a period of 7 days. These conditions could be reversed with the re-addition of EGF and phenol red. The introduction of 600 pM 17β-oestradiol significantly decreased lipogenesis over 7 days without affecting cell division, likely due to abnormal differentiation of sebocytes. Testosterone and dihydrotestosterone, at 1 nM concentrations, did not impact cell division or lipogenesis over the same period. However, 1 μM 13-cis-retinoic acid significantly reduced lipogenesis over 7 days.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    6 / 57 results
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 4 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Switched from finasteride to dutasteride - 2 month update

      in Finasteride/Dutasteride  6 upvotes 1 year ago
      The user switched from finasteride to dutasteride for hair loss treatment, but experienced increased libido, itchy scalp, and accelerated hair loss. Another user suggested that genetic variations might cause dutasteride to be less effective and recommended checking for specific genetic markers.

      community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

      in Research/Science  65 upvotes 1 year ago
      Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.

      community "DHT Itch" and onset Seborrheic Dermatitis

      in Research/Science  76 upvotes 1 year ago
      The post and conversation discuss the link between DHT (a hormone), scalp itchiness, and hair loss. Some users share their experiences and treatments, including the use of fluconazole, corticosteroids, and ketoconazole shampoo, with one user suspecting minoxidil as a potential cause of their symptoms.

    Similar Research

    5 / 1000+ results