Exploring the Efficacy and Potential Mechanisms of Topical Periplaneta Americana Extract in Treating Androgenetic Alopecia in a Mouse Model: A Systems Pharmacology and Skin Microbiome Analysis

    July 2025 in “ Biology ”
    Tianmin Guan, Xin Yang, Hong Chen … Zhengchun He
    Studysummary In this preclinical study, PA-011 derived from Periplaneta americana showed significant hair regrowth effects in androgenetic alopecia mouse models by inhibiting inflammation and oxidative stress, activating hair follicle stem cell proliferation, and normalizing skin microbiota, suggesting promise as an AGA treatment.
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