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Glossary Skin Microbiome

diverse community of microorganisms living on the skin's surface

The skin microbiome, also known as the cutaneous microbiome or skin flora, refers to the diverse community of microorganisms, including bacteria, fungi, viruses, and mites, that reside on the skin's surface. These microorganisms play a crucial role in protecting against pathogens, modulating the immune system, and maintaining skin health. Understanding the skin microbiome is essential for both laypersons and professionals as it has implications for conditions like acne, eczema, and even alopecia.

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Research

5 / 1000+ results

research Advances in the human skin microbiota and its roles in cutaneous diseases

100 citations , August 2022 in “Microbial Cell Factories”

This review discusses the interactions between skin microbiota and human skin health, examining how imbalances may contribute to skin diseases, and reports no new clinical results.

research From stem cells protection to skin microbiota balance: Orobanche rapum extract, a new natural strategy

9 citations , November 2018 in “Journal of cosmetic dermatology”

This study reports that a plant extract from Orobanche rapum can stimulate skin rejuvenation and protect cutaneous microbiota, potentially creating healthier skin.

research Skin microbiota and diabetic foot ulcers

6 citations , July 2025 in “Frontiers in Microbiology”

This study observed that in patients with diabetic foot ulcers, an imbalance in skin microbiota, with increased pathogenic bacteria, contributes to infection and poor wound healing, and suggests that modulating microbiota composition might improve healing outcomes.

research RETRACTED: Gut microbiota, skin microbiota, and alopecia areata: A Mendelian randomization study

4 citations , July 2024 in “Skin Research and Technology”

Certain bacteria may influence alopecia areata risk, but skin bacteria don't mediate gut-skin effects.

research Dynamic remodeling of skin microbiota during healthy homeostatic and wound repair conditions

February 2026 in “Frontiers in Microbiology”

This review examines current understanding of how skin microbiota interact with and influence wound healing, highlighting the roles of commensal microorganisms in inflammation resolution, tissue regeneration, and barrier restoration, and discusses potential microbiota-based therapies for improving wound management.

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Community Join

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community Has anyone tried tretinoin with seb derm and had any flare-ups as a result?

4 upvotes 7 months ago

Tretinoin can irritate seborrheic dermatitis, but using it with a moisturizer on calm skin may help. Parallel Health's skin microbiome testing and phage therapy are suggested for persistent issues.

community Mallia Aesthetics achieves key regulatory steps for novel sCD83-derived ingredient for hair growth

24 upvotes 1 year ago

Mallia Aesthetics has developed MAL-838, a hormone-free product derived from sCD83, which stimulates hair growth without disrupting the skin microbiome. sCD83 promotes hair growth by activating hair follicles and preventing cell death, offering a localized treatment without systemic side effects.

community Gut microbiome imbalances linked to scalp inflammation and hair follicle impact

in Technology 243 upvotes 4 months ago

Gut microbiome imbalances can cause scalp inflammation and affect hair follicles, potentially leading to hair loss. Treatments include finasteride, peptides like BPC-157, TB-500, KPV, and lifestyle changes such as diet and exercise.

community Study: There is 70x Higher Unconjugated DHT in Feces Compared To Blood Levels in Young Adults - Gut Microbiota Manages DHT Recycling and Metabolism

in Research/Science 194 upvotes 1 year ago

Gut microbiota significantly influences androgen metabolism, impacting hair loss treatments like finasteride. Probiotics, dietary changes, and fecal microbiota transplants may help manage DHT levels and improve hair health.

community DHT Harms Scalp Microbiome: DHT Itch is REAL

413 upvotes 1 year ago

Increased Malassezia and Cutibacterium in the scalp microbiome are linked to higher sebum production and inflammation in androgenetic alopecia (AGA). Treatments include ciclopirox shampoo, benzoyl peroxide shampoo, clobetasol propionate, calcipotriol, minoxidil, finasteride, and dutasteride.

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Learn

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learn Melatonin

Can melatonin cause side effects on the skin or hair? No study links melatonin to hair loss; reports are anecdotal. Some users report scalp dryness or irritation from topical products, and a safety review lists mainly mild side effects such as sleepiness and headache.

learn Follistatin

Can follistatin be applied to the skin, and does any form of it treat hair loss? No study shows that follistatin applied to the skin works, and no form of follistatin is an approved or proven hair-loss treatment. Follistatin injections, "research peptides" and gene therapies sold outside regulated trials are unapproved and of unknown safety.

learn Scalp Micropigmentation

Does scalp micropigmentation work on all skin tones and hair colors? Providers say SMP pigment can be matched to many skin tones and hair colors; claims that it works on all of them are marketing.
Is scalp micropigmentation suitable for people with sensitive skin? Providers say scalp micropigmentation suits most skin types and describe patch tests, hypoallergenic pigments and a skin consultation for sensitive skin. These are provider claims rather than independent safety evidence, and pigment reactions remain a risk.

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Clinics

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Experts

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SMP Specialist
Noelle Skin
Nice, France

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Noelle Skin