Periplaneta Americana Extract Promotes Hair Regrowth in Alopecia Areata Mice by Reducing Inflammation and Modulating Skin Microbiota

August 2025 in “ OPAL (Open@LaTrobe) (La Trobe University) ”

Tangfei Guan (20349315), Xin Yang (104842), Canhui Hong (20349312), Jiali Zhu (165939), Peiyun Xiao (20349321), Yongshou Yang (6822419), Chenggui Zhang (9216440), Zhengchun He (20349324)

Periplaneta americana extract alopecia areata inflammation skin microbiota hair follicle cell proliferation TNF-α IL-23 VCAM-1 Wnt3a pathway TGF-β pathway metabolic pathways beneficial bacteria PA-011 AA

TLDR Periplaneta americana extract helps hair regrowth in alopecia areata by reducing inflammation and balancing skin bacteria.

The study investigated the effects of Periplaneta Americana extract (PA-011) on alopecia areata (AA) in mice, focusing on its anti-inflammatory and microbiota-modulating properties. Results showed that PA-011 promoted hair regrowth by enhancing hair follicle cell proliferation and reducing inflammatory markers such as TNF-α, IL-23, and VCAM-1. It also activated the Wnt3a and TGF-β pathways, regulated metabolic pathways, and reversed AA-induced changes in skin microbiota, promoting beneficial bacteria. These findings suggest that PA-011 could be a potential therapeutic option for AA by alleviating skin inflammation and restoring microbiota balance.

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