Polarized Microscopy in Genetic Hair Disorders: Case Series

    January 2025
    Image of study
    TLDR Polarized microscopy helps identify hair irregularities in genetic disorders.
    This study examined the microscopic features of hair in 10 patients with rare genetic disorders using polarized light microscopy. The patients included 6 with Netherton syndrome, 2 with hypotrichosis congenita hereditaria Marie Unna, and 2 with ectodermal dysplasia (Smurf syndrome). Polarized microscopy, a noninvasive diagnostic method, was used to assess hair thickness, microfibrillar composition, and structural anomalies by observing changes in light refraction and coloration. This technique is valuable for identifying hair shaft irregularities and provided significant insights into the alopecia observed in these patients, which is a primary clinical sign of their genetic conditions.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 11 results

      community Results so far on Finasteride and biotin

      in Progress Pictures  145 upvotes 4 years ago
      The conversation is about someone experiencing significant hair regrowth after 23 days on Finasteride and Biotin, with others suggesting additional treatments like Minoxidil and microneedling. Some doubt the speed of hair growth, while others believe Biotin isn't contributing to the results.

      community PYRILUTAMIDE VS RU58841 users which is superior

      in Update  27 upvotes 3 years ago
      Hair loss treatments, with users discussing their experiences with both RU58841 and Pyrilutamide, noting that the latter has only recently become available but may yield better results in the long term.

      community Can we stop fear mongering with finasteride

      in Finasteride/Dutasteride  285 upvotes 5 months ago
      Finasteride is effective for hair loss but can cause sexual dysfunction and mental health issues in some users, leading to a polarized debate on its risks. Some switch to alternatives like Dutasteride or topical treatments to avoid side effects.

      community 9months progress fin/derma pen/minoxidil

      in Progress Pictures  1000 upvotes 5 years ago
      A user's 9 month progress using Finasteride, Derma Pen/Roller and Minoxidil to treat hair loss. Replies in the conversation include advice on topical application of Minoxidil and Dutasteride for regrowth and hair thickness.

      community Age 18 vs Age 25, the importance of starting early

      in Progress Pictures  889 upvotes 1 year ago
      An 18-year-old began using Finasteride and Topical Minoxidil for hair loss, later switching to Oral Minoxidil and Dutasteride by age 25. The conversation emphasizes early treatment, potential side effects, and differing opinions on medication effectiveness.

    Similar Research

    5 / 1000+ results
      Genetic Hair Disorders: A Review

      research Genetic Hair Disorders: A Review

      26 citations , July 2019 in “Dermatology and Therapy”
      The conclusion is that genetic testing is important for diagnosing and treating various genetic hair disorders.
      Hair Disorders

      research Hair Disorders

      November 2019 in “Harper's Textbook of Pediatric Dermatology”
      Understanding normal hair growth and loss in children is key to diagnosing and treating hair disorders.
      The Genetics of Hair Shaft Disorders

      research The Genetics of Hair Shaft Disorders

      59 citations , June 2008 in “Journal of The American Academy of Dermatology”
      The article explains the genetic causes and symptoms of various hair disorders and highlights the need for more research to find treatments.
      Structural Abnormalities of the Hair Shaft

      research Structural Abnormalities of the Hair Shaft

      126 citations , January 1987 in “Journal of The American Academy of Dermatology”
      The document concludes that understanding hair structure is key to diagnosing hair abnormalities and recommends gentle hair care for management.
      Hair Loss in Children

      research Hair Loss in Children

      30 citations , August 1983 in “Pediatric Clinics of North America”
      Most hair loss in children is caused by a few common conditions, and it's important to diagnose these properly and support the child's mental health.