Promotion of Hair Regrowth in Androgenetic Alopecia with Supplemented Erzhi Wan: Exploring Its Mechanism Using Network Pharmacology and Molecular Docking

    Ji Chen, Jing Ma, Feng Chen … Yuegang Wei
    Studysummary This study found that supplemented Erzhi Wan enhanced hair regrowth in a mouse model of androgenetic alopecia and identified potential mechanisms through oxidative stress and signaling pathways.
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    Research cited in this study 21

    1. CXXC5 Mediates DHT-Induced Androgenetic Alopecia via PGD2 Cells · 2023
    2. Commensal Microbiome Promotes Hair Follicle Regeneration by Inducing Keratinocyte HIF-1α Signaling and Glutamine Metabolism Science Advances · 2023
    3. Exploring the Mechanisms and Molecular Targets of Taohong Siwu Decoction for the Treatment of Androgenetic Alopecia Based on Network Analysis and Molecular Docking Clinical, Cosmetic and Investigational Dermatology · 2022
    4. Alleviation of Androgenetic Alopecia with Aqueous Paeonia Lactiflora and Poria Cocos Extract Intake Through Suppressing the Steroid Hormone and Inflammatory Pathway Pharmaceuticals · 2021
    5. Quercitrin Stimulates Hair Growth with Enhanced Expression of Growth Factors via Activation of MAPK/CREB Signaling Pathway Molecules · 2020
    6. PI3K/Akt Signaling Pathway Is Essential for De Novo Hair Follicle Regeneration Stem Cell Research & Therapy · 2020
    7. Physiopathology and Current Treatments of Androgenetic Alopecia: Going Beyond Androgens and Anti-Androgens Dermatologic Therapy · 2019
    8. An Overview of Herbal Alternatives in Androgenetic Alopecia Journal of Cosmetic Dermatology · 2019
    9. Serenoa Repens Extracts Promote Hair Regeneration and Repair of Hair Loss in Mouse Models by Activating TGF-β and Mitochondrial Signaling Pathway PubMed · 2018
    10. Oxidative Stress in Androgenetic Alopecia PubMed · 2017
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    12. The Role of Oxidative Stress in Early-Onset Androgenetic Alopecia Journal of Cosmetic Dermatology · 2016
    13. Oxidative Stress-Associated Senescence in Dermal Papilla Cells of Men with Androgenetic Alopecia Journal of Investigative Dermatology · 2015
    14. Potential Targets in the Discovery of New Hair Growth Promoters for Androgenic Alopecia Expert Opinion on Therapeutic Targets · 2014
    15. Hair Growth-Promoting Activity of Hot Water Extract of Thuja Orientalis BMC Complementary and Alternative Medicine · 2013
    16. Quality of Life Assessment in Male Patients with Androgenetic Alopecia: Results of a Prospective, Multicenter Study Annals of Dermatology · 2012
    17. Melanocyte Stem Cells: A Melanocyte Reservoir in Hair Follicles for Hair and Skin Pigmentation Pigment Cell & Melanoma Research · 2011
    18. Prevalence of Androgenetic Alopecia in China: A Community-Based Study in Six Cities British Journal of Dermatology · 2010
    19. Premature Senescence of Balding Dermal Papilla Cells In Vitro Is Associated With p16INK4a Expression Journal of Investigative Dermatology · 2007
    20. Hair Follicle Pigmentation: Mechanisms and Factors Influencing Melanin Production ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2005
    21. The Hair Growth Promoting Effect of Sophora Flavescens Extract and Its Molecular Regulation Journal of Dermatological Science · 2002