Promotion of Hair Regrowth in Androgenetic Alopecia with Supplemented Erzhi Wan: Exploring Its Mechanism Using Network Pharmacology and Molecular Docking

October 2023 in “ Clinical, Cosmetic and Investigational Dermatology ”

Ji Chen, Jing Ma, Feng Chen, Haibin Zhu, Yumei Gao, Jun Huang, Hui Shan, Yuegang Wei

androgenetic alopecia Supplemented Erzhi Wan quercetin luteolin kaempferol oxidative stress gland development chemical stress PI3K/Akt signaling pathway AGE-RAGE signaling pathway AGA SEZW

TLDR Supplemented Erzhi Wan may help regrow hair in male pattern baldness by affecting certain cell signaling pathways.

The study investigated the effectiveness of a Traditional Chinese Medicine formula, Supplemented Erzhi Wan (SEZW), in treating Androgenetic Alopecia (AGA) in 40 male mice. After 28 days of treatment, the SEZW-treated groups showed significantly higher hair regeneration scores and hair weight compared to the AGA-model group. The study identified 200 molecules targeted by the active compounds in SEZW and 1385 AGA-related genes. The primary active compounds in SEZW were found to be quercetin, luteolin, and kaempferol. The mechanism of action of SEZW in treating AGA may be related to oxidative stress, gland development, and chemical stress, with the PI3K/Akt and AGE-RAGE signaling pathways identified as potential therapeutic pathways. However, large-scale clinical studies are needed to confirm these results. The study was approved by relevant ethics committees and funded by several science foundations.

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