PI3K/Akt Signaling Pathway Is Essential for De Novo Hair Follicle Regeneration

April 2020 in “ Stem Cell Research & Therapy ”

Yu Chen, Zhimeng Fan, Xiaoxiao Wang, Miaohua Mo, Shu Bin Zeng, Ren-He Xu, Xusheng Wang, Yaojiong Wu

PI3K/Akt signaling pathway hair follicle regeneration epidermal stem cells skin-derived precursors platelet-rich plasma quiescent hair follicle stem cells PRP

TLDR PI3K/Akt pathway is crucial for hair growth and regeneration.

A study published in Stem Cell Research & Therapy found that the PI3K/Akt signaling pathway is essential for de novo hair follicle regeneration. The study used epidermal stem cells and skin-derived precursors from mice to investigate the molecular mechanisms of hair follicle regeneration. The researchers found that inhibiting the PI3K/Akt pathway significantly suppressed regeneration and identified it as crucial for the process. The study suggests potential therapeutic applications for enhancing hair regeneration. Platelet-rich plasma (PRP) may also promote hair regrowth by activating quiescent hair follicle stem cells to proliferate.

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