PI3K/Akt Signaling Pathway Is Essential for De Novo Hair Follicle Regeneration

April 2020 in “ Stem Cell Research & Therapy ”

Yu Chen, Zhimeng Fan, Xiaoxiao Wang, Miaohua Mo, Shu Bin Zeng, Ren-He Xu, Xusheng Wang, Yaojiong Wu

PI3K/Akt signaling pathway hair follicle regeneration epidermal stem cells skin-derived precursors platelet-rich plasma quiescent hair follicle stem cells PRP

TLDR PI3K/Akt pathway is crucial for hair growth and regeneration.

A study published in Stem Cell Research & Therapy found that the PI3K/Akt signaling pathway is essential for de novo hair follicle regeneration. The study used epidermal stem cells and skin-derived precursors from mice to investigate the molecular mechanisms of hair follicle regeneration. The researchers found that inhibiting the PI3K/Akt pathway significantly suppressed regeneration and identified it as crucial for the process. The study suggests potential therapeutic applications for enhancing hair regeneration. Platelet-rich plasma (PRP) may also promote hair regrowth by activating quiescent hair follicle stem cells to proliferate.

View this study on stemcellres.biomedcentral.com →

Discuss this study in the Community →

Research cited in this study

25 / 25 results

research Platelet Sonicates Activate Hair Follicle Stem Cells And Mediate Enhanced Hair Follicle Regeneration

16 citations, December 2019 in “Journal of Cellular and Molecular Medicine”

Sonicated platelet-rich plasma boosts hair growth by activating stem cells.

research Autologous Cellular Method Using Micrografts of Human Adipose Tissue Derived Follicle Stem Cells in Androgenic Alopecia

88 citations, July 2019 in “International Journal of Molecular Sciences”

Using human fat tissue derived stem cells in micrografts can safely and effectively increase hair density in people with hair loss.

research Long-Term Expansion and Differentiation of Adult Murine Epidermal Stem Cells in 3D Organoid Cultures

67 citations, June 2019 in “Proceedings of the National Academy of Sciences”

A new 3D culture system helps grow and study mouse skin stem cells for a long time.

research Alopecia and Platelet-Derived Therapies

23 citations, November 2017 in “Stem cell investigation”

Platelet lysate is more effective than activated autologous platelet-rich plasma or saline in improving hair growth after hair restoration surgery.

research Platelet-Rich Plasma Stimulates Angiogenesis in Mice Which May Promote Hair Growth

14 citations, October 2017 in “European Journal of Medical Research”

Platelet-rich plasma can help grow more and longer hair by creating new blood vessels.

Stem Cells from Human Hair Follicles: First Mechanical Isolation for Immediate Autologous Clinical Use in Androgenetic Alopecia and Hair Loss

research Stem Cells from Human Hair Follicles: First Mechanical Isolation for Immediate Autologous Clinical Use in Androgenetic Alopecia and Hair Loss

86 citations, June 2017 in “Stem cell investigation”

Stem cells from hair follicles can safely treat hair loss.

research Macrophages Induce AKT/β-Catenin-Dependent Lgr5+ Stem Cell Activation and Hair Follicle Regeneration Through TNF

117 citations, March 2017 in “Nature Communications”

Macrophages help regrow hair by activating stem cells using AKT/β-catenin and TNF.

Evaluation of Non-Activated and Activated PRP in Hair Loss Treatment: Role of Growth Factor and Cytokine Concentrations Obtained by Different Collection Systems

research Evaluation of Non-Activated and Activated PRP in Hair Loss Treatment: Role of Growth Factor and Cytokine Concentrations Obtained by Different Collection Systems

136 citations, February 2017 in “International Journal of Molecular Sciences”

PRP treatment improves hair growth, and the device used can affect results, with some being more effective.

research Functional Hair Follicle Regeneration by the Rearrangement of Stem Cells

8 citations, January 2017 in “Methods in molecular biology”

Stem cells rearrangement regenerates functional hair follicles, potentially treating hair loss.

research Hair Follicle and Sebaceous Gland De Novo Regeneration With Cultured Epidermal Stem Cells and Skin-Derived Precursors

44 citations, July 2016 in “Stem Cells Translational Medicine”

Scientists discovered that certain stem cells from mice and humans can be used to grow new hair follicles and skin glands when treated with a special mixture.

research The Effect of Platelet-Rich Plasma in Hair Regrowth: A Randomized Placebo-Controlled Trial

214 citations, September 2015 in “Stem Cells Translational Medicine”

Platelet-rich plasma injections significantly improved hair regrowth and thickness in patients with hair loss.

research An Integrated Transcriptome Atlas of Embryonic Hair Follicle Progenitors, Their Niche, and the Developing Skin

173 citations, August 2015 in “Developmental cell”

The study identified unique genes in hair follicle cells and their environment, suggesting these genes help organize cells for hair growth.

research Promotional Effect of Platelet-Rich Plasma on Hair Follicle Reconstitution In Vivo

63 citations, October 2013 in “Dermatologic Surgery”

Platelet-Rich Plasma (PRP) increases the number of new hair follicles and speeds up hair formation.

research Fgf9 From Dermal γδ T Cells Induces Hair Follicle Neogenesis After Wounding

237 citations, June 2013 in “Nature Medicine”

A protein from certain immune cells is key for new hair growth after skin injury in mice.

A Randomized, Double-Blind, Placebo- and Active-Controlled, Half-Head Study to Evaluate the Effects of Platelet-Rich Plasma on Alopecia Areata

research A Randomized, Double-Blind, Placebo- and Active-Controlled, Half-Head Study to Evaluate the Effects of Platelet-Rich Plasma on Alopecia Areata

205 citations, April 2013 in “British Journal of Dermatology”

Platelet-rich plasma treatment significantly increased hair regrowth and decreased discomfort in alopecia patients, making it a potentially better and safer treatment option.

research Mesenchymal–Epithelial Interactions During Hair Follicle Morphogenesis and Cycling

300 citations, August 2012 in “Seminars in Cell & Developmental Biology”

The conclusion is that certain cell interactions and signals are crucial for hair growth and regeneration.

research Autologous Platelet-Rich Plasma: A Potential Therapeutic Tool for Promoting Hair Growth

270 citations, March 2012 in “Dermatologic Surgery”

Platelet-rich plasma can potentially promote hair growth by stimulating cell growth and increasing certain proteins.

Dermal β-Catenin Activity in Response to Epidermal Wnt Ligands Is Required for Fibroblast Proliferation and Hair Follicle Initiation

research Dermal β-Catenin Activity in Response to Epidermal Wnt Ligands Is Required for Fibroblast Proliferation and Hair Follicle Initiation

207 citations, March 2012 in “Development”

Skin needs dermal β-catenin activity for hair growth and skin cell multiplication.

research Hair Follicle Regeneration in Skin Grafts: Current Concepts and Future Perspectives

39 citations, September 2011 in “Tissue Engineering Part B-reviews”

Hair follicle regeneration in skin grafts may be possible using stem cells and tissue engineering.

research SKPs Derive from Hair Follicle Precursors and Exhibit Properties of Adult Dermal Stem Cells

330 citations, December 2009 in “Cell stem cell”

SKPs are similar to adult skin stem cells and could help in skin repair and hair growth.

research Epidermal Homeostasis: A Balancing Act of Stem Cells in the Skin

1039 citations, February 2009 in “Nature Reviews Molecular Cell Biology”

Skin stem cells are crucial for maintaining and repairing the skin and hair, using a complex mix of signals to do so.

research Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells

835 citations, October 2008 in “Nature Genetics”

Lgr5 is a marker for active, long-lasting stem cells in mouse hair follicles.

research Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding

829 citations, May 2007 in “Nature”

Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.

research Scratching the Surface of Skin Development

788 citations, February 2007 in “Nature”

The document concludes that skin stem cells are important for hair growth and wound healing, and could be used in regenerative medicine.

research Molecular Principles of Hair Follicle Induction and Morphogenesis

479 citations, January 2005 in “BioEssays”

Hair follicle development is controlled by interactions between skin tissues and specific molecular signals.

Related Research

5 / 5 results