Functional Hair Follicle Regeneration by the Rearrangement of Stem Cells

January 2017 in “ Methods in molecular biology ”

Kyosuke Asakawa, Koh-ei Toyoshima, Takashi Tsuji

hair follicle regeneration stem cells epithelial cells mesenchymal cells dorsal skin vibrissae follicle cells enzymatic reactions centrifugation

TLDR Stem cells rearrangement regenerates functional hair follicles, potentially treating hair loss.

The paper describes a method for functional hair follicle regeneration through the rearrangement of stem cells. The study involves the preparation of single epithelial and mesenchymal cells from the dorsal skin of embryonic mice, as well as the preparation of adult mouse vibrissae follicle cells. The process involves enzymatic reactions and centrifugation to isolate the necessary cells. The study provides detailed instructions for the preparation of these cells and their subsequent use in hair follicle regeneration. In 2012, researchers successfully regenerated fully functional hair follicles in mice by rearranging stem cells and their niches. This method could potentially be used for hair loss treatment in humans.

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Research cited in this study

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