Functional Hair Follicle Regeneration by the Rearrangement of Stem Cells

January 2017 in “ Methods in molecular biology ”

Kyosuke Asakawa, Koh-ei Toyoshima, Takashi Tsuji

hair follicle regeneration stem cells epithelial cells mesenchymal cells dorsal skin vibrissae follicle cells enzymatic reactions centrifugation

TLDR Stem cells rearrangement regenerates functional hair follicles, potentially treating hair loss.

The paper describes a method for functional hair follicle regeneration through the rearrangement of stem cells. The study involves the preparation of single epithelial and mesenchymal cells from the dorsal skin of embryonic mice, as well as the preparation of adult mouse vibrissae follicle cells. The process involves enzymatic reactions and centrifugation to isolate the necessary cells. The study provides detailed instructions for the preparation of these cells and their subsequent use in hair follicle regeneration. In 2012, researchers successfully regenerated fully functional hair follicles in mice by rearranging stem cells and their niches. This method could potentially be used for hair loss treatment in humans.

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Scientists successfully created and transplanted bioengineered hair follicles that function like natural ones, suggesting a new treatment for hair loss.

research Fully Functional Hair Follicle Regeneration Through the Rearrangement of Stem Cells and Their Niches

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Regenerated fully functional hair follicles using stem cells, with potential for hair regrowth therapy.

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SKPs are similar to adult skin stem cells and could help in skin repair and hair growth.

research The Hair Follicle as a Dynamic Mini-Organ

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research Molecular Dissection of Mesenchymal–Epithelial Interactions in the Hair Follicle

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research Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells

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2 / 2 results

research Functional Hair Follicle Regeneration by the Rearrangement of Stem Cells

8 citations , January 2017 in “Methods in molecular biology”

Stem cells rearrangement regenerates functional hair follicles, potentially treating hair loss.

research Hair Follicle Regeneration In Vitro

December 2016 in “Paleontological Journal”

Hair growth can be induced by transplanting certain cells, but these cells lose their properties during culturing. The best cell interaction happens in a liquid medium under gravity, and using collagen doesn't help. Future research could focus on using growth factors to stimulate these cells.