SKPs Derive from Hair Follicle Precursors and Exhibit Properties of Adult Dermal Stem Cells

December 2009 in “ Cell stem cell ”

Jeffrey Biernaskie, Maryline Paris, Olena Morozova, B. Matthew Fagan, Marco A. Marra, Larysa Pevny, Freda D. Miller

TLDR SKPs are similar to adult skin stem cells and could help in skin repair and hair growth.

The document from December 2009 presents research on skin-derived precursors (SKPs), which are cells that originate from hair follicle precursors and exhibit properties of adult dermal stem cells. SKPs were found to self-renew, differentiate into various dermal cell types, and contribute to hair follicle formation and dermal maintenance. The study involved transplanting SKPs into the skin of mice and rats, with specific numbers of subjects varying across different experiments (e.g., 8 mice or 12 rats for SKP injections, and 6 adult rat SKPs for hair follicle induction assays). The findings suggest that SKPs could have potential applications in regenerative medicine and hair loss treatments due to their ability to induce hair follicle morphogenesis and aid in wound healing.

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Research cited in this study

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research Organogenesis From Dissociated Cells: Generation of Mature Cycling Hair Follicles From Skin-Derived Cells

205 citations, April 2005 in “Journal of Investigative Dermatology”

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Cultured Peribulbar Dermal Sheath Cells Can Induce Hair Follicle Development and Contribute to the Dermal Sheath and Dermal Papilla

research Cultured Peribulbar Dermal Sheath Cells Can Induce Hair Follicle Development and Contribute to the Dermal Sheath and Dermal Papilla

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SKPs Derive from Hair Follicle Precursors and Exhibit Properties of Adult Dermal Stem Cells

Research cited in this study

research Organogenesis From Dissociated Cells: Generation of Mature Cycling Hair Follicles From Skin-Derived Cells

research Cultured Peribulbar Dermal Sheath Cells Can Induce Hair Follicle Development and Contribute to the Dermal Sheath and Dermal Papilla

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