Fully Functional Hair Follicle Regeneration Through the Rearrangement of Stem Cells and Their Niches

    April 2012 in “ Nature Communications
    Koh-ei Toyoshima, Kyosuke Asakawa, Naoko Ishibashi, Hiroshi Toki, Miho Ogawa, Tomoko Hasegawa, Tarou Irie, Tetsuhiko Tachikawa, Akio Sato, Akira Takeda, Takashi Tsuji
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    TLDR Regenerated fully functional hair follicles using stem cells, with potential for hair regrowth therapy.
    This study from 11 years ago successfully regenerated fully functional hair follicles through the rearrangement of stem cells and their niches. The bioengineered hair follicles had the structural properties of natural hair and underwent hair cycles similar to those of natural hair. The study also demonstrated the possibility of reconstituting the niche for arrector pili muscle development, which is essential for functional hair follicle regeneration. The authors suggest that this approach has potential for hair regenerative therapy.
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