Fully Functional Hair Follicle Regeneration Through the Rearrangement of Stem Cells and Their Niches

    April 2012 in “ Nature Communications ”
    Koh-ei Toyoshima, Kyosuke Asakawa, Naoko Ishibashi … Takashi Tsuji
    Studysummary This study demonstrates the potential of using bioengineered follicles from adult tissue-derived stem cells for fully functional hair regeneration, illustrating possible applications in organ replacement therapy.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on nature.com →
    Discuss this study in the Community →

    Research cited in this study 18

    1. The Basement Membrane Of Hair Follicle Stem Cells Is A Muscle Cell Niche Cell · 2011
    2. Microenvironmental Reprogramming of Thymic Epithelial Cells to Skin Multipotent Stem Cells Nature · 2010
    3. SKPs Derive from Hair Follicle Precursors and Exhibit Properties of Adult Dermal Stem Cells Cell stem cell · 2009
    4. Sox2-Positive Dermal Papilla Cells Specify Hair Follicle Type in Mammalian Epidermis Development · 2009
    5. Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis Cell stem cell · 2009
    6. Isolation and Short-Term Culture of Primary Keratinocytes, Hair Follicle Populations, and Dermal Cells from Newborn Mice and Keratinocytes from Adult Mice for In Vitro Analysis and Grafting to Immunodeficient Mice Nature Protocols · 2008
    7. Defining Hair Follicles in the Age of Stem Cell Bioengineering Journal of Investigative Dermatology · 2007
    8. Scratching the Surface of Skin Development Nature · 2007
    9. Bioengineering the Hair Follicle Organogenesis · 2007
    10. Long-Term Renewal of Hair Follicles from Clonogenic Multipotent Stem Cells Proceedings of the National Academy of Sciences of the United States of America · 2005
    11. Organogenesis From Dissociated Cells: Generation of Mature Cycling Hair Follicles From Skin-Derived Cells Journal of Investigative Dermatology · 2005
    12. Hair Follicle Dermal Cells Differentiate Into Adipogenic and Osteogenic Lineages Experimental Dermatology · 2003
    13. A Simple In Vivo System for Studying Epithelialization, Hair Follicle Formation, and Invasion Using Primary Epidermal Cells from Wild-Type and Transgenic Ornithine Decarboxylase-Overexpressing Mouse Skin Journal of Investigative Dermatology · 2001
    14. Hair-Cycle-Associated Remodeling of the Peptidergic Innervation of Murine Skin and Hair Growth Modulation by Neuropeptides Journal of Investigative Dermatology · 2001
    15. Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells Cell · 2001
    16. Human Hair Follicle Regeneration Following Amputation and Grafting into the Nude Mouse Journal of Investigative Dermatology · 1996
    17. Hair Matrix Germinative Epidermal Cells Confer Follicle-Inducing Capabilities on Dermal Sheath and High Passage Papilla Cells Development · 1996
    18. Hormones and Hair Growth: Variations in Androgen Receptor Content of Dermal Papilla Cells Cultured from Human and Red Deer Hair Follicles ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1993

    Related research 4

    1. Stem Cells in Embryonic Skin Development Biological Research · 2012
    2. Epidermal Stem Cells: Practical Perspectives and Potential Uses British Journal of Dermatology · 2009
    3. Therapeutic Potential of Stem Cells in Skin Repair and Regeneration Chinese Journal of Traumatology · 2008
    4. Skin and Hair: Models for Exploring Organ Regeneration Human Molecular Genetics · 2008