Fully Functional Hair Follicle Regeneration Through the Rearrangement of Stem Cells and Their Niches

April 2012 in “ Nature Communications ”

Koh-ei Toyoshima, Kyosuke Asakawa, Naoko Ishibashi, Hiroshi Toki, Miho Ogawa, Tomoko Hasegawa, Tarou Irie, Tetsuhiko Tachikawa, Akio Sato, Akira Takeda, Takashi Tsuji

hair follicle regeneration stem cells niches bioengineered hair follicles hair cycles arrector pili muscle hair regenerative therapy

TLDR Regenerated fully functional hair follicles using stem cells, with potential for hair regrowth therapy.

This study from 11 years ago successfully regenerated fully functional hair follicles through the rearrangement of stem cells and their niches. The bioengineered hair follicles had the structural properties of natural hair and underwent hair cycles similar to those of natural hair. The study also demonstrated the possibility of reconstituting the niche for arrector pili muscle development, which is essential for functional hair follicle regeneration. The authors suggest that this approach has potential for hair regenerative therapy.

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research Human Hair Follicle Regeneration Following Amputation and Grafting into the Nude Mouse

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Human hair follicles can regenerate after removal, but with low success rate.

research Hair Matrix Germinative Epidermal Cells Confer Follicle-Inducing Capabilities on Dermal Sheath and High Passage Papilla Cells

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