Platelet Sonicates Activate Hair Follicle Stem Cells And Mediate Enhanced Hair Follicle Regeneration

    December 2019 in “ Journal of Cellular and Molecular Medicine ”
    Meishu Zhu, Deqiang Kong, Rui-Yun Tian … Yaojiong Wu
    Studysummary This study found that sonicated platelet-rich plasma was more effective than calcium chloride-induced platelet-rich plasma in activating hair follicle stem cells and promoting hair follicle regeneration in mice.
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    Research cited in this study 19

    1. Autologous Cellular Method Using Micrografts of Human Adipose Tissue Derived Follicle Stem Cells in Androgenic Alopecia International Journal of Molecular Sciences · 2019
    2. Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development Cells · 2019
    3. Alopecia and Platelet-Derived Therapies Stem cell investigation · 2017
    4. Platelet-Rich Plasma Stimulates Angiogenesis in Mice Which May Promote Hair Growth European Journal of Medical Research · 2017
    5. Stem Cells from Human Hair Follicles: First Mechanical Isolation for Immediate Autologous Clinical Use in Androgenetic Alopecia and Hair Loss Stem cell investigation · 2017
    6. As a Carrier–Transporter for Hair Follicle Reconstitution, Platelet-Rich Plasma Promotes Proliferation and Induction of Mouse Dermal Papilla Cells Scientific Reports · 2017
    7. Macrophages Induce AKT/β-Catenin-Dependent Lgr5+ Stem Cell Activation and Hair Follicle Regeneration Through TNF Nature Communications · 2017
    8. Platelet-Rich Plasma for Androgenetic Alopecia: Does It Work? Evidence from Meta-Analysis Journal of Cosmetic Dermatology · 2017
    9. Hair Follicle and Sebaceous Gland De Novo Regeneration With Cultured Epidermal Stem Cells and Skin-Derived Precursors Stem Cells Translational Medicine · 2016
    10. The Effect of Platelet-Rich Plasma in Hair Regrowth: A Randomized Placebo-Controlled Trial Stem Cells Translational Medicine · 2015
    11. Promotional Effect of Platelet-Rich Plasma on Hair Follicle Reconstitution In Vivo Dermatologic Surgery · 2013
    12. A Randomized, Double-Blind, Placebo- and Active-Controlled, Half-Head Study to Evaluate the Effects of Platelet-Rich Plasma on Alopecia Areata British Journal of Dermatology · 2013
    13. Autologous Platelet-Rich Plasma: A Potential Therapeutic Tool for Promoting Hair Growth Dermatologic Surgery · 2012
    14. SKPs Derive from Hair Follicle Precursors and Exhibit Properties of Adult Dermal Stem Cells Cell stem cell · 2009
    15. Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells Nature Genetics · 2008
    16. PDGF Isoforms Induce and Maintain Anagen Phase of Murine Hair Follicles Journal of Dermatological Science · 2006
    17. Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis Nature Medicine · 2005
    18. In Vivo Promoted Growth of Mice Hair Follicles by the Controlled Release of Growth Factors Biomaterials · 2003
    19. Growth Factor and Growth Factor Receptor Localization in the Hair Follicle Bulge and Associated Tissue in Human Fetus Journal of Investigative Dermatology · 1996

    Related research 4

    1. Gab1 and MAPK Signaling Are Essential in the Hair Cycle and Hair Follicle Stem Cell Quiescence Cell reports · 2015
    2. Live Imaging of Stem Cell and Progeny Behavior in Physiological Hair-Follicle Regeneration Nature · 2012
    3. Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration Cell · 2011
    4. Skin and Hair: Models for Exploring Organ Regeneration Human Molecular Genetics · 2008