In Vivo Promoted Growth of Mice Hair Follicles by the Controlled Release of Growth Factors

April 2003 in “ Biomaterials ”

Makoto Ozeki, Yasuhiko Tabata

growth factors basic fibroblast growth factor bFGF hepatocyte growth factor HGF vascular endothelial growth factor VEGF biodegradable gelatin hydrogel collagen hydrogel hair follicle growth hair shaft length gelatin hydrogel

Studysummary This study found that the controlled release of specific growth factors from biodegradable hydrogels significantly enhanced hair follicle growth and hair shaft length in mice compared to growth factors in solution.

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This study investigated the effects of controlled release of growth factors on hair follicle growth in mice. Basic fibroblast growth factor (bFGF) and hepatocyte growth factor (HGF) were incorporated into a biodegradable gelatin hydrogel, while vascular endothelial growth factor (VEGF) was incorporated into a collagen hydrogel. After subcutaneous implantation into mice, the hydrogels significantly increased hair follicle size and hair shaft length compared to growth factors in solution form and empty hydrogels. The study concluded that controlled release of growth factors via hydrogels positively influenced hair growth cycles in mice.

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research Promoted Growth of Murine Hair Follicles Through Controlled Release of Vascular Endothelial Growth Factor

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This study found that controlled release of VEGF via a collagen hydrogel promoted hair follicle growth and cell proliferation in mice more effectively than free VEGF injections.

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This study found that insulin-like growth factor-I and hepatocyte growth factor increased the chemotactic migration of human hair outer root sheath cells, suggesting these factors have both growth stimulatory and chemotactic effects.

research Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis

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This study found that VEGF significantly enhances perifollicular vascularization during the hair growth phase, accelerating hair regrowth and increasing follicle and hair size, while its inhibition retards hair growth.

research Local Injection of Hepatocyte Growth Factor/Scatter Factor Alters Cyclic Growth of Murine Hair Follicles

109 citations , April 1998 in “Journal of Investigative Dermatology”

This study found that recombinant human HGF/SF injections altered hair follicle growth cycles and mildly promoted hair elongation in mice, depending on their hair cycle stage.

Growth Factors and Cytokines in Hair Follicle Development and Cycling: Recent Insights from Animal Models and the Potentials for Clinical Therapy

research Growth Factors and Cytokines in Hair Follicle Development and Cycling: Recent Insights from Animal Models and the Potentials for Clinical Therapy

100 citations , November 1996 in “Molecular Medicine Today”

This review discusses the role of growth factors and cytokines in hair follicle development and cycling, but reports no new clinical findings on treatments for hair growth disorders.

research Growth Factors in Hair Organ Development and the Hair Growth Cycle

90 citations , October 1996 in “Dermatologic Clinics”

This study found that red ginseng oil may enhance hair growth and protect skin from UV damage in mouse models by promoting regenerative processes and reducing inflammation.

research Fibroblast Growth Factor Influences the Development and Cycling of Murine Hair Follicles

58 citations , April 1993 in “Developmental Biology”

This study found that subcutaneous injections of basic fibroblast growth factor in neonatal mice delayed the development and hair growth cycles of hair follicles compared to controls.

Effects of Epidermal Growth Factor, Fibroblast Growth Factor, Minoxidil, and Hydrocortisone on Growth Kinetics in Human Hair Bulb Papilla Cells and Root Sheath Fibroblasts Cultured In Vitro

research Effects of Epidermal Growth Factor, Fibroblast Growth Factor, Minoxidil, and Hydrocortisone on Growth Kinetics in Human Hair Bulb Papilla Cells and Root Sheath Fibroblasts Cultured In Vitro

58 citations , June 1987 in “Archives of Dermatological Research”

This study found that epidermal and fibroblast growth factors increased proliferation of human hair bulb papilla cells and root sheath fibroblasts in vitro, while hydrocortisone decreased it and minoxidil had no effect.