The Chemotactic Effect of a Dermal Papilla Cell-Derived Factor on Outer Root Sheath Cells

April 2001 in “ Journal of Dermatological Science ”

Takeshi Fujie, Shoji Katoh, Hajimu Oura, Yoshio Urano, Seiji Arase

dermal papilla cells outer root sheath cells insulin-like growth factor-I hepatocyte growth factor vascular endothelial growth factor transforming growth factor-β1 paracrine factor hair follicle epithelial cells chemotaxis epithelial keratinocytes DPCs ORSCs IGF-I HGF VEGF TGF-β1

Studysummary This study found that insulin-like growth factor-I and hepatocyte growth factor increased the chemotactic migration of human hair outer root sheath cells, suggesting these factors have both growth stimulatory and chemotactic effects.

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