Hair Growth-Promoting Effect of Geranium Sibiricum Extract in Human Dermal Papilla Cells and C57BL/6 Mice

February 2017 in “ BMC Complementary and Alternative Medicine ”

William A. Boisvert, Miri Yu, Young-Bin Choi, Gi Hee Jeong, Yilin Zhang, Sunghun Cho, Changsun Choi, Sang-Hyun Lee

TLDR Geranium sibiricum extract helps hair grow and is more effective than minoxidil but can be toxic in high concentrations.

In the 2017 study, Geranium sibiricum extract (GSE) was found to promote hair growth in human dermal papilla cells (hDPCs) and C57BL/6 mice. GSE was more effective than minoxidil in proliferating and migrating hDPCs, and it significantly stimulated the expression of Ki-67 protein and increased mRNA levels of hepatocyte growth factor and vascular endothelial growth factor in hDPCs. Topical application of GSE on mice resulted in significant hair growth, with histological analysis showing an active anagen phase and induction of stem cell factor. GSE also reduced the number of mast cells and the expression of transforming growth factor beta 1 in mouse skin tissues. However, GSE concentrations above 156.3 µg/mL were toxic to hDPCs. The study concluded that GSE could promote hair growth by enhancing cell proliferation and migration, reducing inflammation, and upregulating growth factor expression.

View this study on bmccomplementalternmed.biomedcentral.com →

Discuss this study in the Community →

Research cited in this study

15 / 15 results

research Neuroendocrinology of the Hair Follicle: Principles and Clinical Perspectives

98 citations , July 2014 in “Trends in Molecular Medicine”

Hair follicles are hormone-sensitive and involved in growth and other functions, with potential for new treatments, but more research is needed.

research Effects of Glucocorticoid on Human Dermal Papilla Cells In Vitro

27 citations , December 2012 in “The Journal of Steroid Biochemistry and Molecular Biology”

Dexamethasone may cause hair loss by stopping cell growth.

research Androgen Actions on the Human Hair Follicle: Perspectives

115 citations , September 2012 in “Experimental Dermatology”

Androgens have complex effects on hair growth, promoting it in some areas but causing hair loss in others, and our understanding of this is still evolving.

research Hair Growth Promoting Effect of Zizyphus Jujuba Essential Oil

73 citations , March 2010 in “Food and Chemical Toxicology”

Zizyphus jujuba essential oil can promote hair growth.

research The Hair Cycle

375 citations , February 2006 in “Journal of Cell Science”

The document concludes that the hair cycle is a complex process involving growth, regression, and rest phases, regulated by various molecular signals.

research Biological Characterization of Cultured Dermal Papilla Cells and Hair Follicle Regeneration In Vitro and In Vivo

24 citations , February 2006 in “Chinese Medical Journal”

Cultured dermal papilla cells can regenerate hair follicles and sustain hair growth.

research An Open, Randomized, Comparative Study of Oral Finasteride and 5% Topical Minoxidil in Male Androgenetic Alopecia

71 citations , January 2004 in “Dermatology”

Oral finasteride works better than topical minoxidil for hair growth, both are safe.

research Molecular Control of Epithelial-Mesenchymal Interactions During Hair Follicle Cycling

277 citations , June 2003 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings”

Epithelial-mesenchymal interactions control hair growth cycles through specific molecular signals.

research Onion Juice (Allium Cepa L.), A New Topical Treatment For Alopecia Areata

95 citations , June 2002 in “The Journal of Dermatology”

Onion juice is more effective than tap water for hair re-growth in patchy alopecia areata.

research Hair Growth Effect of Minoxidil

25 citations , January 2002 in “Folia Pharmacologica Japonica”

Minoxidil helps hair grow by improving blood flow and increasing growth factors in hair follicles.

research Photographic Documentation of the Effectiveness of 1 mg Oral Finasteride in the Treatment of Androgenic Alopecia in Men in Routine General Practice in Switzerland

4 citations , November 2001 in “PubMed”

1 mg/day oral finasteride significantly improves hair growth in men with male pattern baldness.

research Finasteride

125 citations , January 1999 in “Drugs”

Finasteride effectively treats baldness but may cause sexual side effects.

research Lipid Peroxides Induce Early Onset of Catagen Phase in Murine Hair Cycles

49 citations , January 1998 in “International Journal of Molecular Medicine”

Lipid peroxides can cause early hair loss by damaging hair follicles.

research Biphasic Effects of Minoxidil on the Proliferation and Differentiation of Normal Human Keratinocytes

34 citations , January 1997 in “Skin Pharmacology and Physiology”

Minoxidil affects cell growth in two ways: low doses increase growth, while high doses slow it down and can be toxic.

research Effects of Epidermal Growth Factor on the Morphology and Patterns of DNA Synthesis in Isolated Human Hair Follicles

94 citations , February 1994 in “The journal of investigative dermatology/Journal of investigative dermatology”

EGF makes hair follicles grow longer but stops hair production.

Related Research

7 / 7 results

The Potential Role of Fibroblast-Derived Multi-Peptide Factors in Activation of Growth Factors and Beta-Catenin in Hair Follicle Cells

research The Potential Role of Fibroblast-Derived Multi-Peptide Factors in Activation of Growth Factors and Beta-Catenin in Hair Follicle Cells

4 citations , June 2022 in “Journal of Cosmetic Dermatology”

Multi-peptide factors from fibroblasts may stimulate hair growth by increasing growth factors and β-catenin in hair cells.

Hair Growth-Promoting Effects of Camellia Seed Cake Extract in Human Dermal Papilla Cells and C57BL/6 Mice

research Correlation Between Hair Physiology and Hair Loss

November 2005

Some factors can either promote or inhibit hair growth.

research Promoted Growth of Murine Hair Follicles by Controlled Release of Growth Factors from Biodegradable Hydrogel

June 2005 in “Key Engineering Materials”

Using hydrogels to slowly release growth factors can effectively boost hair growth in mice.

research The Chemotactic Effect of a Dermal Papilla Cell-Derived Factor on Outer Root Sheath Cells

47 citations , April 2001 in “Journal of Dermatological Science”

IGF-I and HGF attract and stimulate hair follicle cells to move.