The Potential Role of Fibroblast-Derived Multi-Peptide Factors in Activation of Growth Factors and Beta-Catenin in Hair Follicle Cells

July 2022 in “ Journal of Cosmetic Dermatology ”

Jung-Hye Shin, Young-Yoon Lee, Kyung Min Kim, Kyung Shin Won, Sang Bum Suh, Dongkyun Hong, Kwang Hwa Jung, Chang Deok Kim, Young‐Joon Seo, Sung Bin Cho, Young Lee

multi-peptide factors dermal fibroblast-conditioned medium outer root sheath cells dermal papilla cells keratinocyte growth factor vascular endothelial growth factor epidermal growth factor β-catenin hair follicle cells MPFs DFCM ORS cells DP cells KGF VEGF EGF

TLDR Multi-peptide factors from fibroblasts may stimulate hair growth by increasing growth factors and β-catenin in hair cells.

The study investigated the effects of multi-peptide factors (MPFs) contained in dermal fibroblast-conditioned medium (DFCM) on hair growth. The DFCM was prepared using human neonatal dermal fibroblasts and used to culture outer root sheath (ORS) and dermal papilla (DP) cells. The results showed that MPF-containing DFCM increased the expression of keratinocyte growth factor (KGF), vascular endothelial growth factor (VEGF), and epidermal growth factor (EGF) mRNA in ORS cells, and KGF and VEGF mRNA in DP cells. Additionally, the secretion of several growth factors was increased in the cell-cultured medium when ORS cells were treated with MPF-containing DFCM. The study also found that MPF-containing DFCM increased the transcriptional activation of β-catenin in DP cells. The findings suggest that MPF-containing DFCM might stimulate hair growth by inducing growth factors in ORS and DP cells and regulating β-catenin in DP cells.

View this study on onlinelibrary.wiley.com →

Discuss this study in the Community →

Cited in this study

7 / 7 results

research Hedgehog Signaling in Papillary Fibroblasts Is Essential for Hair Follicle Regeneration During Wound Healing

5 citations , December 2021 in “Journal of Investigative Dermatology”

Hedgehog signaling in certain cells is crucial for hair growth during wound healing.

research More Is Not Always Better in Hair Growth Factors: Epidermal Growth Factor Involved in Alopecia Areata Pathogenesis

4 citations , January 2020 in “International Journal of Trichology”

Too much epidermal growth factor can cause hair loss.

research Further Clinical Evidence for the Effect of IGF-1 on Hair Growth and Alopecia

29 citations , August 2017 in “Skin appendage disorders”

IGF-1 may affect hair growth and loss, but more research is needed to confirm effective and safe treatments.

research Insulin-Like Growth Factor-1: Roles in Androgenetic Alopecia

27 citations , March 2014 in “Experimental Dermatology”

IGF-1 affects hair loss and could be a potential treatment.

research Signaling Involved in Hair Follicle Morphogenesis and Development

223 citations , January 2014 in “International Journal of Molecular Sciences”

The conclusion is that proper signaling is crucial for hair growth and development, and errors can lead to cancer or hair loss.

research Hematological And Hepatic Effects Of Vascular Epidermal Growth Factor (VEGF) Used To Stimulate Hair Growth In An Animal Model

30 citations , October 2013 in “BMC dermatology”

VEGF gel increases hair growth but may have potential toxicity.

research Fibroblast Growth Factor and Epidermal Growth Factor in Hair Development.

28 citations , July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology”

7 / 7 results

research Possible Cellular Communication with Human Follicle Dermal Papilla Cells via Secretions from Human Hair Follicle Keratinocytes

January 2022 in “Journal of St. Marianna University”

Substances from human hair cells can affect hair loss-related genes, potentially leading to new treatments for baldness.

research Multifaceted Role of Hair Follicle Dermal Cells in Bioengineered Skins

33 citations , March 2017 in “British journal of dermatology/British journal of dermatology, Supplement”

Human hair follicle dermal cells can effectively replace other cells in engineered skin.

research A Model System to Analyze the Ability of Human Keratinocytes to Form Hair Follicles

15 citations , May 2014 in “Experimental Dermatology”

Scientists developed a system to study human hair growth using skin cells, which could help understand hair development and improve skin substitutes for medical use.

research Review of Hair Follicle Dermal Cells

321 citations , January 2010 in “Journal of Dermatological Science”

Dermal cells are key in controlling hair growth and could potentially be used in hair loss treatments, but more research is needed to improve hair regeneration methods.